1. Acute pancreatites

2. Pancreas Complicated exocrine and endocrine gland located in the upper abdominal region Non-capsulated lobular organ about 12 to 20 cm long and lies behind the peritoneum of the posterior abdominal wall Divided into head, body, and tail

3. Acute pancreatitis ranges from a mild, self- limited disorder to a severe, rapidly fatal disease that does not respond to any treatment. Mild acute pancreatitis is characterized by edema and inflammation confined to the pancreas Acute Pancreatitis

4. Minimal organ dysfunction is present, and return to normal function usually occurs within 6 months. Although this is considered the milder form of pancreatitis, the patient is acutely ill and at risk for hypovolemic shock, fluid and electrolyte disturbances, and sepsis

5. Pathophysiology Self-digestion of the pancreas by its own proteolytic enzymes, principally trypsin, causes acute pancreatitis. Eighty percent of patients with acute pancreatitis have biliary tract disease

6. Gallstones enter the common bile duct and lodge at the ampulla of Vater, obstructing the flow of pancreatic juice or causing a reflux of bile from the common bile duct into the pancreatic duct, thus activating the powerful enzymes within the pancreas. Normally, these remain in an inactive form until the pancreatic secretions reach the lumen of the duodenum. Activation of the enzymes can lead to vasodilation, increased vascular permeability, necrosis, erosion, and hemorrhage

7. Long-term use of alcohol is commonly associated with acute episodes of pancreatitis Other, less common causes of pancreatitis include bacterial or viral infection, with pancreatitis occasionally developing as a complication of mumps virus.

8. Blunt abdominal trauma peptic ulcer disease ischemic vascular disease hyperlipidemia use of corticosteroids thiazide diuretics, oral contraceptives, and other medications have also been associated with an increased incidence of pancreatitis

9. The overall mortality rate of patients with acute pancreatitis is high (10%) because of shock, anoxia, hypotension, or fluid and electrolyte imbalances. Attacks of acute pancreatitis may result in complete recovery, may recur without permanent damage, or may progress to chronic pancreatitis

10. Clinical Manifestations 1. sever abdominal pain 2. back pain 3. edema of the inflamed pancreas 4. abdominal distention 5. Nausea and vomiting 6. Fever, jaundice, mental confusion, and agitation may also occur

11. Hypotension is typical and reflects hypovolemia and shock. In addition to hypotension, the patient may develop tachycardia, cyanosis, and cold, clammy skin. Acute renal failure is common.

12. Respiratory distress and hypoxia are common, and the patient may develop diffuse pulmonary infiltrates, dyspnea, tachypnea, and abnormal blood gas values. Myocardial depression, hyperglycemia, and disseminated intravascular coagulation (DIC) may also occur with acute pancreatitis.

13. Assessment and Diagnostic Findings The diagnosis of acute pancreatitis is based on a history of abdominal pain, the presence of known risk factors, physical examination findings, and diagnostic findings. Serum amylase and lipase levels are used in making the diagnosis of acute pancreatitis.

14. In 90% of the cases, serum amylase and lipase levels rise in excess of three times their normal upper limit within 24 hours. Serum amylase usually returns to normal within 48 to 72 hours, but serum lipase levels may remain elevated for 5 to 7 days.Urinary amylase levels also become elevated and remain elevated longer than serum amylase levels

15. The white blood cell count is usually elevated. Transient hyperglycemia and glucosuria and elevated serum bilirubin levels occur in some patients with acute pancreatitis.

16. X-ray studies of the abdomen and chest may be obtained to differentiate pancreatitis from other disorders that can cause similar symptoms and to detect pleural effusions. Ultrasound and contrast-enhanced computed tomographic (CT) scans are used to identify an increase in the diameter of the pancreas and to detect pancreatic cysts, abscesses

17. Hematocrit and hemoglobin levels are used to monitor the patient for bleeding. Peritoneal fluid, obtained through paracentesis or peritoneal lavage, may contain increased levels of pancreatic enzymes. The stools of patients with pancreatic disease are often bulky, pale, and foul-smelling

18. Medical Management Management of acute pancreatitis is directed toward relieving symptoms and preventing or treating complications. All oral intake is withheld, to inhibit stimulation of the pancreas and its secretion of enzymes. Parenteral nutrition is usually an important part of therapy, particularly in debilitated patients, because of the extreme metabolic stress associated with acute pancreatitis

19. The current recommendation is that, whenever possible, the enteral route should be used to meet nutritional needs in patients with pancreatitis. Patients who do not tolerate enteral feeding require parenteral nutrition.Nasogastric suction may be used to relieve nausea and vomiting and to decrease painful abdominal distention and paralytic ileus

20. Histamine-2 (H2) antagonists such as cimetidine (Tagamet) and ranitidine (Zantac) may be prescribed to decrease pancreatic activity by inhibiting secretion of hydrogen chloride. Proton pump inhibitors such as pantoprazole (Protonix) may be used for patients who do not tolerate H2 antagonists or for whom this therapy is ineffective.

21. Pain Management Adequate administration of analgesia is essential during the course of acute pancreatitis to provide sufficient pain relief and to minimize restlessness, which may stimulate pancreatic secretion further.

22. Intensive Care where hemodynamic monitoring and arterial blood gas monitoring are initiated. Antibiotic agents may be prescribed if infection is present. The role of prophylactic antibiotics is controversial and still under study. Insulin may be required if hyperglycemia occurs. Correction of fluid and blood loss is necessary to maintain fluid volume and prevent renal failure

23. Respiratory Care Aggressive respiratory care is indicated because of the high risk for elevation of the diaphragm, pulmonary infiltrates and effusion, and atelectasis. Hypoxemia occurs in a significant number of patients with acute pancreatitis, even with normal x-ray findings

24. Surgical Intervention Although surgery is often risky because the acutely ill patient is a poor surgical risk, it may be performed to assist in the diagnosis of pancreatitis (diagnostic laparotomy), to establish pancreatic drainage, or to resect or débride a necrotic pancreas. The patient who undergoes pancreatic surgery may have multiple drains in place postoperatively, as well as a surgical incision that is left open for irrigation and repacking every 2 to 3 days to remove necrotic debris.

25. Post acute Management Antacids may be used after acute pancreatitis begins to resolve. Oral feedings that are low in fat and protein are initiated gradually. Caffeine and alcohol are eliminated from the diet. If the episode of pancreatitis occurred during treatment with thiazide diuretics, corticosteroids, or oral contraceptives, these medications are discontinued

26. Nursing Interventions 1. Relieving Pain and Discomfort 2. Nasogastric suction may be used to relieve nausea and vomiting or to treat abdominal distention 3. Improving Breathing Pattern : The nurse maintains the patient in a semi-Fowler's position 4.Frequent changes of position are necessary to prevent atelectasis and pooling of respiratory secretions

27. 5. Improving Nutritional Status:Laboratory test results and daily weights are useful to monitor the nutritional status.

28. Nursing Diagnoses Acute pain related to inflammation, edema, distention of the pancreas, and peritoneal irritation Ineffective breathing pattern related to severe pain, pulmonary infiltrates, pleural effusion, atelectasis, and elevated diaphragm Imbalanced nutrition, less than body requirements, related to reduced food intake and increased metabolic demands Impaired skin integrity related to poor nutritional status, bed rest, multiple drains, and surgical wound