1. Research on Potential Anti-Cancer Drugs Bill Denny Auckland Cancer Society Research Center Design drugs that intercalate between DNA bases. Structure? Teixeira et al. (2005), work submitted for publication. Attack DNA => Attack fast dividing cells Cancer = Uncontrolled growth. Cells need DNA to divide.

2. Design drugs that intercalate between DNA bases. Structure? Research on Potential Anti-Cancer Drugs Bill Denny Auckland Cancer Society Research Center Christine Cardin, UK University of Reading Ricardo Leal ESRF/ILL/Keele University PhD student Trevor Forsyth ILL/Keele University Shirley Miles ILL/Keele University PhD student Deuteration Laboratory Ed Mitchell ESRF Teixeira et al. (2005), work submitted for publication. Susana Teixeira ILL/Keele University Postdoc

3. How drugs work: Zooming in on the structure! Drug Design Neutron Studies @ ILL X-Ray Crystallography @ESRF DNA structure DNA: Fibers, Crystals, Solutions H – Bonds DNA distortion Sample Preparation @ Deuteration Lab.