1. Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Novel Approach for Anterior Chamber Angle Analysis: Anterior Chamber Angle Detection With Edge Measurement and Identification Algorithm (ACADEMIA) Arch Ophthalmol. 2006;124(10):1395-1401. doi:10.1001/archopht.124.10.1395 Measuring trabecular-iris angle (TIA) and angle opening distance 500 (AOD 500). A, Trabecular-iris angle is defined as an angle measured with the apex in the iris recess and the arms of the angle passing through a point on the trabecular meshwork 500 μm from the scleral spur and the point on the iris perpendicularly. B, Angle opening distance 500 is defined as the distance from the corneal endothelium to the anterior iris surface perpendicular to a line drawn along the trabecular meshwork at 500 μm from the scleral spur. Figure Legend:

2. Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Novel Approach for Anterior Chamber Angle Analysis: Anterior Chamber Angle Detection With Edge Measurement and Identification Algorithm (ACADEMIA) Arch Ophthalmol. 2006;124(10):1395-1401. doi:10.1001/archopht.124.10.1395 Steps for measuring anterior chamber angles with the ACADEMIA (anterior chamber angle detection with edge measurement and identification algorithm). UBM indicates ultrasound biomicroscopic. Figure Legend:

3. Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Novel Approach for Anterior Chamber Angle Analysis: Anterior Chamber Angle Detection With Edge Measurement and Identification Algorithm (ACADEMIA) Arch Ophthalmol. 2006;124(10):1395-1401. doi:10.1001/archopht.124.10.1395 Three basic types of angle configuration were identified: constant (A), increasing (B), and decreasing (C) angle profiles corresponding to flat, bowed forward, and bowed backward iris contours, respectively. D, Irregular profile not conforming to any of the mentioned patterns because of the irregularity of the anterior iris surface. The characteristic profiles of the angle configurations cannot be revealed when plotting the angle opening distance (AOD) against the distance from the scleral spur. Figure Legend:

4. Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Novel Approach for Anterior Chamber Angle Analysis: Anterior Chamber Angle Detection With Edge Measurement and Identification Algorithm (ACADEMIA) Arch Ophthalmol. 2006;124(10):1395-1401. doi:10.1001/archopht.124.10.1395 Scatterplot of the average ACADEMIA (anterior chamber angle detection with edge measurement and identification algorithm) angle against the angle opening distance 500 (AOD 500). Figure Legend:

5. Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Novel Approach for Anterior Chamber Angle Analysis: Anterior Chamber Angle Detection With Edge Measurement and Identification Algorithm (ACADEMIA) Arch Ophthalmol. 2006;124(10):1395-1401. doi:10.1001/archopht.124.10.1395 The ACADEMIA (anterior chamber angle detection with edge measurement and identification algorithm) angle profiles of angle A and angle B. Although angle B appeared narrower than angle A in the ultrasound biomicroscopic images, both angles demonstrate similar angle opening distance 500 (AOD 500) measurements. In contrast, the ACADEMIA angle and the profile are able to show the difference between the dimensions and the configurations of the angles. Figure Legend:

6. Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Novel Approach for Anterior Chamber Angle Analysis: Anterior Chamber Angle Detection With Edge Measurement and Identification Algorithm (ACADEMIA) Arch Ophthalmol. 2006;124(10):1395-1401. doi:10.1001/archopht.124.10.1395 Schematic representation of angle A and angle B illustrating the limitation of angle opening distance 500 (AOD 500) in quantifying the angle dimensions. Figure Legend: