1. Occlusion Device for Patent Ductus Arteriosus Christina Mathieson & Trung Nguyen Advisor: Dr. Tom Doyle BME 273 – Senior Design Project

2. Patent Ductus Arteriosus (PDA) Vessel connecting aorta and pulmonary artery Necessary prior to birth Usually closes by 21 st day of life Abnormal if patent after 3 months 1 in 2000 births

3. PDA Shapes A: funnel B: window C: tubular D: aneurysmal E: elongated cone

4. PDA Sizes Narrowest segment average: 3.2±1.0 mm Range: 2 mm – 8 mm Length is highly variable (mm – cm) Size variable regardless of shape

5. Current Treatments Drug therapy – indomethacin Surgery Occlusion devices –Portsmann plug –Rashkind double umbrella –Adjustable buttoned device –Double ballon device –Coils

6. Our Goals PDA occlusion device Delivered via small catheter Effective for all ages Conforms to various shapes of PDA Able to retract and reposition Biocompatible material (foam) Low cost

7. Project Timeline DecJanFebMarApr Research*** Advisor Meeting***** Material Decision ** Design*** Prototype*** Testing***

8. Work Completed Research –PDA background –Current treatments Brainstorming device shapes –Mushroom –Pipe-cleaner

9. Current Work Researching –Materials –Delivery methods Brainstorming ideas for device shape Meeting with Dr. Doyle

10. Future Work Brainstorm more ideas –Shapes –Delivery mechanisms Analyze ideas Look into methods of testing device