1. Marcos Rojkind MD, Ph.D Professor of Biochemistry and Molecular Biology and Pathology Phone (202) 994-2789 E-mail: bcmmmr@gwumc.edu

2. Quiescent Stellate Cell Hepatic Sinusoid Hepatocytes Space of Disse Kupffer Cell Endothelial Cell COURTESY OF DR. SCOTT FRIEDMAN

3. 1.EXPRESSION OF RECEPTORS TO GROWTH FACTOR AND CYTOKINES: PDGF- and TGF-  receptors. 2. INCREASED MIGRATION AND PROLIFERATION IN RESPONSE TO GROWTH FACTORS. Migration towards the injured site. 3. INCREASED PRODUCTION OF EXTRACELLULAR MATRIX COMPONENTS. Production of scar tissue. 4. ELIMINATION OF MYOFIBROBLASTS BY APOPTOSIS AND SCAR RESOLUTION. Decreased expression of TIMP 1 DIFFERENTIATION OF HEPATIC STELLATE CELLS

4. AlcoholAcetaldehyde Wnt Fibrosis Cancer Oxidative Stress TGF-  AlcoholAcetaldehyde Wnt Fibrosis Cancer Oxidative Stress TGF- 

5. ACH H 2 O 2 Wnt activation GSK3  inhibition Nuclear  -catenin translocation EtOH Smad 3/4 TGF-  P HSC differentiation Hepatocyte proliferation Transcription of C-Myc and Cyclin D1