2. Measure ANYTHING in the –omics age…. BIGNORANCE Driven Research

4. Curated Co-occurrence p < 0.05 Implied information p > 0.05 40 x 10 7 1,500 40,404,412 possible gene-disease pairs 487,871 Co-occurrence p > 0.05 375,213 Implied information p < 0.05 1,520,897 38,395,644

5. Tim Clark In San Diego (Feb 2011, Beyond the PDF) ‘I challenge you to capture your talk in nanopublications’ Thank you!

6. Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context

7. Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) provenanc e context Cognitive Deficits (S) Cognitive Deficits (S) BACE1 (O) BACE1 (O) Relate to (p) Relate to (p) Σ provenance Σ context Σ context E E 10 14 10 11

8. (Large) data sets produces Data Intensive Science Data Intensive Science produces Narrative articles Narrative articles Proper UUID Proper UUID have Tables, figures Tables, figures contain Don’t have ‘Claims’ contain yield Citation Metrics Citation Metrics Are used for Professional Awards Professional Awards Are used for Are not used for Don’t support Community Annotation Community Annotation needs Data Sharing Data Sharing needs Don’t support Does not yield Difficult to be Found by Difficult to be Found by Text & Data mining Text & Data mining Don’t support Link to Don’t have

9. Data Intensive Science Data Intensive Science (Large) data sets produces Nano publications Nano publications Tables, figures Tables, figures Proper UUID Proper UUID have Can represent C a n r e p r e s e n t have Can represent support Professional Awards Professional Awards yield Citation Metrics Citation Metrics Can be used for Are used for Can be used for Support Community Annotation Community Annotation needs Data Sharing Data Sharing yields needs support Can be found using Narrative Articles support s u p p o r t describe d e s c r i b e provenance p r o v e n a n c e context c o n t e x t Mining & annotation Mining & annotation support ‘Claims’

10. √e Cardinal Assertion With computed evidence score Cognitive deficit. is related to. BACE1 1 1 2 2 3 3 √e 5 5 4 4 New nanopublication UUID Original publication NP1 NP2 NP3…n Any Research object 4 4

11. (>>>nanopubs)

12. (Large) data sets Data Intensive Science Data Intensive Science produces Narrative articles Narrative articles Proper UUID Proper UUID have Tables, figures Tables, figures contain ‘Claims’ contain yield Citation Metrics Citation Metrics Are used for Professional Awards Professional Awards Community Annotation Community Annotation needs Data Sharing Data Sharing Don’t support Text & Data mining Text & Data mining Don’t support Link to Knowlet now is: Cluster of all assertions With the same subject

13. The Knowledge Discovery Window In silico knowledge discovery needs Computer Reasonable formats