1. William Sanford Karissa Thoma Dan Frost Allie Finney Client: Dr. Mark Reichelderfer Advisor: Dr. Willis Tompkins

2. Overview 1.Background 2.Problem Statement 3.Design Constraints 4.Previous design work 5.Lab Jacks 6.Pressure Sensor Sealants 7.Future Work

3. Esophageal Strictures Dysphagia= dys  with difficulty +phagia  with eating Causes GERD majority 25% other problems Eosinophilic esophagitis UW-Hospital, Dr. Mark Reichelderfer

4. Eosinophilic Esophagitis Adolescents and young men History of food and environmental allergies Difficult to treat: Associated with mucosal tearing and perforation http://www.nature.com/gi mo/contents/pt1/images/g imo49-f4.jpg

5. Dilation Balloon Dilates radially increasing lumen TTS scope (through the scope) Perforations Dependent on: Clinician’s experience Equipment http://www.dkimages.com/discover/previews/881/28882. JPG http://homepages.cae.wisc.edu/~bme40 2/esophageal_structures_s06/images/ba lloondialation.bmp

6. Problem Statement Measure pressure in balloon Graph volume/pressure curve in real time Obtain test data on tissue compliance Be aesthetically pleasing for hospital setting Eventually be commercially available

7. Design Constraints Work with current dilation procedure Provide real time data Safety Equip laptop for hospital use Provide warning of esophageal perforation Compact enough for hospital setting

8. Previous Work Syringe is filled with saline Pressure measured with disposable pressure transducer Volume measured with linear potentiometer Outputs are connected to computer Designed LabVIEW circuit for real time graph Seashore, K. et. al. (2006). Device for Dilating Esophageal Strictures.

9. LabVIEW Circuit

10. Lab Jacks-LabJack U12 Pros Built-in power supply Large input range LabVIEW compatible USB-based Cons Cost No -5V supply http://www.labjack.com/labjack_u12.php?p rodId=27

11. PMD-1208LS Pros USB Power supply LabVIEW compatible Cons No -5V supply Poor user interface http://www- zeuthen.desy.de/apewww/APE/hardware/APEmille/Temperat ure/PMD-1208LS.pdf

12. LabJack UE9 Pro Pros Wireless transmission USB LabVIEW compatible Cons Cost Bulky http://www.labjack.com/labjack_ue9.php?prodId=46

13. WeightU12PMDUE9 Power Supply 2516 Inputs20 User friendly 10859 LabVIEW20 Size1513 9 Cost10590 Total100828374 LabJack Matrix

14. Metal adhesives - MK 1325 Pros High strength Thread sealant Low viscosity Cons Irreversible From Germany http://www.bestklebstoffe.com/media/datenblaetter/englisch/tiMK1325ERev001.pdf?PHPSESSID=952e86e08d406e9e05 a6b976cf39c2e4

15. Gorilla Glue Pros Waterproof Good for dissimilar surfaces Thread sealant Easy to obtain Cons Glue expansion http://www.gorillaglue.com/home/gorilla-glue/product-detail.aspx

16. Megaloc Pros 12000 Psi strength Thread sealant Non-toxic Inexpensive Cons http://www.herchem.com/specs/megaloc.pdf

17. Sealant Matrix 2 WeightMK 1325GorillaMegaloc Strength50 3045 Reversibility10053 Toxicity20 Ease of use5455 Availability5153 Cost10?99 Total100757485

18. Future Work Fix pressure sensor Obtain 10 atm seal Configure device with Lab Jack Configure to hospital laptop IRB approval/testing

19. References Fass, R. M. (2008). Approach to the patient with dysphagia. Retrieved Jan. 31, 2008 from Moises, G. M. (2008). Complications of esophageal stricture dilation. Retrieved Jan 31, 2008 from Moises, G. M. (2008). Management of benign esophageal strictures. Retrieved Jan. 31 2008, 2008 from www.uptodate.com www.uptodate.com