1. Trans-oral microendoscopic KTP-532 Laser assisted excision of Hypopharngeal cancer - a case series Dr.Dipak Ranjan Nayak, Dr.Balakrishnan R, Dr.Suraj Nair Department of ENT- Head and neck surgery, KMC Manipal. 25/ 28 patients disease free on last follow up. 8 salvage surgery for radio-residual disease. (T2-3, T3-4, T4-1) 3 patients had locoregional recurrence. T1 and T2 : no recurrence. T3 : 1 case locoregional recurrence at 3yrs refused further treatment. T4 : 2 cases :1 – TLPE and gastric pull-up 1 – locoregional recurrence at 2 years,refused treatment.  2 patients had lung metastasis after 3 years.  Overall survival rate : 82.14%..  2 year disease free survival rate : 89.4 %. Golden rule of resection is cranio-caudal. Small tumors : monobloc removal. Large tumors : resection in multiple segments.  Presence of metastatic nodes does not preclude endoscopic resection of primary.  Advantages of endoscopic laser excision : -Better precision -Less blood loss -Reduced hospital stay -Organ preservation -Better quality of life -Less post-op edema -Radiotherapy and open surgery are still an option in case of failure.  Limitations : - Severe oral submucous fibrosis. - Cervical spondylosis. - Glottic spread. - Skilled surgeon. - N= 28 : biopsy proven hypopharyngeal cancer. -Time period : 2000 -2014 (14 years) -26 males and 2 females -Age range : 43 to 76 years -Follow-up period – min. 15 months.  All patients underwent trans-oral micro- endoscopic KTP-532 laser assisted excision of growth. -8 patient were radioresidual. -Post-op neck dissection in N positive patients. -Post-op Radiotherapy given to 20 patients.  No tracheostomy or revision surgery needed in any patient. -Cricopharyngeal myotomy done in 9 patients. - Trans-oral endoscopic laser surgery has improved the quality of life and oncological safety. - Owing to a decreased burden for the patient and its cost effectiveness, this method gained wide acceptance. - A careful selection of patients and tumors is of high importance. -10% of upper aerodigestive tract tumours. -Sites : pyriform fossa > post-cricoid >ppw.. - Hasslinger developed the distensible laryngoscope and Seiffert the chest support. -Benefit of organ preservation and minimal morbidity. -KTP -532 laser provides better hemostasis and depth of penetration.. INTRODUCTION METHODS AND MATERIALS 1.Ambrosch P. Laser im oberen Aerodigestivtrakt bei bösartigen Erkrankungen [Lasers in the upper aerodigestive tract in malignant diseases]. Laryngorhinootologie. 2003 May;82 Suppl 1:S114-43. DOI: 10.1055/s-2003-38924. 2.Eckel HE, Staar S, Volling P, Sittel C, Damm M, Jungehuelsing M. Surgical treatment for hypopharynx carcinoma: feasibility, mortality, and results. Otolaryngol Head Neck Surg. 2001 May;124(5):561-9. DOI: 10.1067/mhn.2001.115060. 3.Steiner W, Ambrosch P, Hess CF, Kron M. Organ preservation by transoral laser microsurgery in piriform sinus carcinoma. Otolaryngol Head Neck Surg. 2001 Jan;124(1):58-67. CONCLUSIONS DISCUSSION RESULTS REFERENCES KAPLAN-MEIR SURVIVAL GRAPH. StageNo of cases n= 28 Recurrence/Distant metastases(DM)/ Total Laryngectomy(TLPE) T103No recurrence T209No recurrence T31201 ( refused treatment) T40402 ( 1- TLPE, 1- refused treatment) N013No recurrence N110No recurrence N20503 ( 2 Refused treatment + 1 TLPE) M12 cases (lung) after 3 years I4No recurrence II6No recurrence III131 (refused treatment) IV52 (1 TLPE, 1 refused treatment) Pre-op Post-op Intra-op Post-op