1. ABSTRACT We present and evaluate a dynamic model to predict blood oxygen saturation from respiration signals for use in automated sleep apnea detection. The model uses the averaged integral of a signal representing the respiration magnitude entering the lungs. This signal affects changes in blood oxygen saturation level through standard respiration processes. The results demonstrate that the approach provides reliable and robust estimation of blood oxygen saturation using only the respiration signal. Furthermore, the model may be incorporated in automated sleep apnea detection algorithms that can lead to inexpensive and reliable sleep apnea detection that do not require an overnight stay in the hospital for polysomnogram recordings. INTRODUCTION Sleep apnea syndrome is a serious respiratory disorder defined as an interruption of normal respiration during sleep. The most common type of sleep apnea is obstructive sleep apnea (OSA) characterized by a transient but repetitive reduction or cessation of airflow caused by partial or total collapse of the upper airway during sleep. OSA is an important health problem that can lead to reduced daytime work performance and is related to accidents and health problems. Some studies link sleep apnea to atrial fibrillation, stroke, myocardial infarction and sudden cardiac death [1]. A diagnosis of OSA syndrome requires full-night multi-channel monitoring by means of overnight polysomnography (PSG) [2]. However, a PSG study is both costly and complex requiring manual human analysis to scan and score the entire sleep record. This is a tedious and time consuming task that delays diagnosis and treatment. Some research has been done to develop monitoring devices that can detect sleep apnea with comparable accuracy to the PSG but using a small number of sensors and the elimination of the need for lengthy in-lab monitoring. To address one component of this problem we develop a dynamic model to estimate SpO2 by using respiratory data in sleep apnea. In our model, we consider three signals that are available in polysomnographic records: airflow, abdominal excursion and SpO2. Airflow, abdominal excursion and SpO2 are commonly used measurement signals used to characterize breathing. These signals provide useful information for sleep apnea diagnosis and interpretation. We first illustrate these signals for both normal (Figure 1) and disturbance breathing (Figure 2). Figure 1: Normal Sleep Using Respiration Data to Predict Oxygen Saturation for Sleep Apnea Detection Prapan Shewinvanakitkul, Marc Buchner, Kenneth A. Loparo Department of Electrical Engineering and Computer Science, Case Western Reserve University Figure 2: Obstructive Sleep Apnea Respiratory Data Fo Fo - L Xo Estimate SpO2 Figure 3: Illustrates the relationship between the average airflow and the average SpO2 values. Figure 5: The result from the estimation of SpO2 by using the system in figure 4. However, looking closely we find a problem in some limited situations when the airflow level is increased and decreased over a relatively short period, then the estimated SpO2 levels are not changed properly all of the time. The estimated SpO2 in our system is mainly dependent on the characteristic of airflow data. Figure 6: The problem from the estimation of SpO2 by using the airflow data. Figure 7: The result from the estimation of SpO2 by using the abdominal movements data. We further use the result from the SpO2 estimation to predict drops in oxygen saturation as used in sleep apnea detection. We determine SpO2 desaturation from the baseline by using both the actual SpO2 and the estimated SpO2 from abdominal data. The baseline saturation was set to 92% as the average of SpO2 during sleep. Saturation drop was defined as a decrease of SpO2 by 3% from the baseline for at least 10 seconds. The saturation drop rate was calculated as the saturation drop divided by time in seconds. The results in figure 8 show the duration over which SpO2 desaturation was detected. The estimated SpO2 can capture most of the duration from the desaturation detection as compared to the actual SpO2. Figure 8: The result from the SpO2 desaturation detection. CONCLUSIONS & FUTURE WORK In this study, we presented a model to predict SpO2 that can be used as a component in a sleep apnea detection process. The results demonstrate that the model has reliable estimation of SpO2 using respiration data and is relatively accurate. Future research will focus on the incorporation of the model in automated sleep apnea detection algorithms that can lead to inexpensive and reliable obstructive sleep apnea testing that does not require an overnight stay in the hospital for a polysomnogram but which can be performed at the patient’s home [3]. REFERENCES 1.F. Lopez-Jimenez, F. H. Sert, A. Gami, and V. K. Somers, “Obstructive sleep apnea. Implications for cardiac and vascular disease,” Chest, vol. 133, pp. 793 – 804, 2008. 2.W. W. Flemons, M. R. Littner, J. A. Rowlet, P. Gay, W. M. Anderson, D. W. Hudgel, R. D. McEvoy, and D. I. Loube, “Home diagnosis of sleep apnea: A systematic review of the literature,” Chest, vol. 124, pp. 1543−1579, 2003. 3.Abraham Otero, Santiago F. Dapena, Paulo Felix, Jesus Presedo, Miguel Tarasc o, “A Low Cost Screening Test for Obstructive Sleep Apnea that can be Performed at the Patient’s Home,” 6 th IEEE International Symposium on Intelligent Signal Processing, 2009. L