1. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner by Angela C. Hirbe, Özge Uluçkan, Elizabeth A. Morgan, Mark C. Eagleton, Julie L. Prior, David Piwnica-Worms, Kathryn Trinkaus, Anthony Apicelli, and Katherine Weilbaecher Blood Volume 109(8):3424-3431 April 15, 2007 ©2007 by American Society of Hematology

2. G-CSF enhances OC activity and increases bone resorption in vivo. Angela C. Hirbe et al. Blood 2007;109:3424-3431 ©2007 by American Society of Hematology

3. G-CSF enhances osteoclastogenesis in vitro. Angela C. Hirbe et al. Blood 2007;109:3424-3431 ©2007 by American Society of Hematology

4. G-CSF administration increases tumor burden in bone in vivo. Angela C. Hirbe et al. Blood 2007;109:3424-3431 ©2007 by American Society of Hematology

5. Enhanced tumor growth in bone following G-CSF administration is not seen in OC-defective mice. Angela C. Hirbe et al. Blood 2007;109:3424-3431 ©2007 by American Society of Hematology

6. Tumor growth in bone is increased following G-CSF administration and is decreased by OC blockade in a second osteolytic model. Angela C. Hirbe et al. Blood 2007;109:3424-3431 ©2007 by American Society of Hematology

7. G-CSF administration does not affect subcutaneous tumor growth. Angela C. Hirbe et al. Blood 2007;109:3424-3431 ©2007 by American Society of Hematology

8. Increased tumor growth occurs independently of neutrophil mobilization. Angela C. Hirbe et al. Blood 2007;109:3424-3431 ©2007 by American Society of Hematology