1. Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All- Cause Mortality J Am Coll Cardiol. 2013;62(12):1043-1051. doi:10.1016/j.jacc.2013.06.035 The Relationship Between Coffee Consumption and Subsequent Type 2 Diabetes Mellitus in Different Categories of Coffee Consumption The center of each black square is placed at the summary point estimate; the area of the square is proportional to the population size; and each vertical line shows the 95% confidence interval about the summary estimate. Figure Legend:

2. Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All- Cause Mortality J Am Coll Cardiol. 2013;62(12):1043-1051. doi:10.1016/j.jacc.2013.06.035 Adjusted Hazard Ratios for Risk of Death as a Function of Coffee Consumption Association of daily coffee consumption with total and heart disease mortality among men (A) and women (B). Error bars indicate 95% confidence interval. Figure Legend:

3. Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All- Cause Mortality J Am Coll Cardiol. 2013;62(12):1043-1051. doi:10.1016/j.jacc.2013.06.035 Coffee and Risk of Heart Failure Association between heart failure and cups of coffee per day compared with no consumption. Relative risk (solid line) and 95% CI (dashed lines). Figure Legend:

4. Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All- Cause Mortality J Am Coll Cardiol. 2013;62(12):1043-1051. doi:10.1016/j.jacc.2013.06.035 Coffee Consumption and Risk of Arrhythmias Adjusted hazard ratio (no coffee take is referent = 1) of arrhythmia diagnoses by coffee intake. Error bars indicate 95% confidence interval (CI). Adapted from Klatsky et al. (31). AF = atrial fibrillation; SVT = supraventricular tachycardia. Figure Legend:

5. Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All- Cause Mortality J Am Coll Cardiol. 2013;62(12):1043-1051. doi:10.1016/j.jacc.2013.06.035 Coffee Intake in Diabetic Subjects Adjusted hazard ratios of total, cardiovascular (CV) disease, coronary heart disease (CHD), and stroke mortality by volume of coffee consumption among subjects with type 2 diabetes mellitus. Error bars indicate 95% confidence interval (CI). Figure Legend:

6. Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All- Cause Mortality J Am Coll Cardiol. 2013;62(12):1043-1051. doi:10.1016/j.jacc.2013.06.035 Coffee Over Age 65 Relative risk of cardiovascular disease (CVD) and heart disease mortality by level of caffeinated beverage intake in individuals 65 years of age and older. Error bars indicate 95% confidence interval (CI). Figure Legend:

7. Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All- Cause Mortality J Am Coll Cardiol. 2013;62(12):1043-1051. doi:10.1016/j.jacc.2013.06.035 Coffee and Depression Multivariate-adjusted relative risk (RR) of clinical depression according to caffeine consumption (p for trend = 0.02). Error bars indicate 95% confidence interval. Figure Legend: