1. Standad and Novel Biomarkers for Ovarian Cancer 최문선 ∙ 정희윤 1

2. I.Ovarian Cancer II.Biomarkers 2

3. I.Ovarian Cancer ◆ Female reproductive organs 3

4. I.Ovarian Cancer 4 − EPITHELIAL OVARIAN CANCER (90%) − Serous carcinoma − Mucinous carcinoma − Endometroid carcinoma ◆ Category of Ovarian cancer

5. I.Ovarian Cancer 5 ◆ Ovarian cancer incidence and mortality Mortality 매년 200,000 명의 난소암 환자중 120,000 이 사망 대략적인 사망률 60%

6. I.Ovarian Cancer 6 ◆ ovarian cancer is Silent killer

7. I.Ovarian Cancer 7 ◆ ovarian cancer is Silent killer 전체적으로 60% 의 사망률 30 년 전이나 지금이나 의료기기의 발전에도 불구하고 사망률은 같음 25~30% 초기진단

8. I.Ovarian Cancer 8 ◆ Bone of ovarian cancer 여성의 호르몬 노화 방사선 생활 습관 환경적요인 유전적요인 BRCA1, BRCA2 의 돌연변이 (5~10%)

9. I.Ovarian Cancer II.Biomarkers 9

10. ◆ Biomarker a substance used as an indicator of a biological state I. 실험과저 II. Biomarker * as an indicator of… Normal biological processes, Pathogenic processes, Responses to a therapy, etc. 10

11. I. 실험과저 II. Biomarker CA125 Mesothelin HE4 ◆ Biomarkers for ovarian cancer 11

12. I. 실험과저 II. Biomarker ① Monitor the response to treatment. ② Detect if cancer has come back after treatment is complete. ③ Test and monitor high-risk women who have a family history of ovarian cancer but don’t have the disease. 1. CA125 CA125 as a biomarker 12

13. I. 실험과저 II. Biomarker 1. CA125 It’s NOT a good screening test for ovarian cancer. Non-specificity Poor sensitivity for early-stage cancers Need for new biomarkers However, it’s not perfect. 13

14. I. 실험과저 II. Biomarker 2. Mesothelin 14 Limited expression in normal tissues High expression in several cancers − 40kDa protein − Differentiation antigen on normal mesothelial cells

15. 15 Raffit Hassan, Mesothelin: A New Target for Immunotherapy, Clinical Cancer Research, Vol. 10. : pp.3937-3942 (2004) I. 실험과저 II. Biomarker 2. Mesothelin “ Measure the level of mesothelin in the blood ”

16. I. 실험과저 II. Biomarker 3. HE4 16 (Human Epididymis protein 4) − 11kDa secreted protein − Precursor of the E4 (*E4 : epididymal secretory protein ) − in the blood of ovarian cancer patients, the level

17. I. 실험과저 II. Biomarker 3. HE4 17 (Human Epididymis protein 4) 1. Promising as a biomarker for early detection 2. Complement CA125 3. CA125 + HE4 ▶▶ Highest-level sensitivity Highest-level speciticity

18. I. 실험과저 II. Biomarker 18 # Diagnostic accuracy of ovarian biomarkers

19. Thank you 19