4. Skin colour depends mainly on MELANIN in the Stratum Corneum
INTRODUCTION - Melanin
Skin colour depends mainly on MELANIN in the Stratum Corneum
EUMELANIN
PHEOMELANIN
DARKER
LIGHTER
Its localized accumulation leads to
HYPER PIGMENTATION & SKIN SPOTS

5. Skin colour depends mainly on MELANIN in the Stratum Corneum
INTRODUCTION - Melanin
Skin colour depends mainly on MELANIN in the Stratum Corneum
MELANIN LEVELS
Stress
Drugs
Smoke
Age
Hormonal variations
UV radiation

6. DE-PIGMENTING PRODUCTS
INTRODUCTION - Melanin
Melanin imbalance is the main cause of
HYPER PIGMENTATION and SKIN SPOTS
(Treated with)
DE-PIGMENTING PRODUCTS

7. Today’s skin lightnening ingredients on the market are based on :
SAFETY
Today’s skin lightnening ingredients on the market are based on :
HYDROQUINONE or its derivatives
Not allowed In Europe
Not safe
ARBUTIN
Not safe
(Still allowed)
Composed by ingredients present in human body, low toxicological profile :
HYDROXYAPATITE: 97% of the teeth enamel, 70% of the dentin and bones are composed by hydroxyapatite;
GLUTATHIONE: powerful antioxidant, essential for the production of anti-inflammatory substances, essential in the elimination of toxic by-products of the metabolism;
CYSTEINE: food additive for different nutritional purposes
VERY
SAFE

9. Electrostatic Interaction (Van der Walls)
CYSTEINE
(CYS)
GLUTATHIONE (GSH)
HYDROXYAPATITE (HAP)
Electrostatic Interaction (Van der Walls)

10. INNOVATIVE SKIN LIGHTENING ACTIVE INGREDIENT
HYDROXYAPATITE is able to deliver
CYSTEINE and GLUTATHIONE
enhancing
Skin lightening and de-pigmenting complex activity and efficacy

11. PROTECTION FROM OXYGEN ACTION MORE BIOCOMPATIBLE DELIVERY SYSTEM
MECHANISM OF ACTION: HYDROXYAPATITE
IMPROVED SKIN HEALTH
PROTECTION FROM OXYGEN ACTION
MORE BIOCOMPATIBLE DELIVERY SYSTEM
CONSTANT RELEASE OF ACTIVES IN TIME
PROTECTION FROM FREE RADICALS
+ ANTIAGE EFFECTS (INCREASED ELASTICITY, DECREASED ROUGHNESS, SOFTFOCUS EFFECTS)

12. SKIN LIGHTENING DIRECT INHIBITION OF TYROSINASE ENZYME
MECHANISM OF ACTION: GLUTATHIONE
DIRECT INHIBITION OF TYROSINASE ENZYME
INHIBITION OF TYROSINASE ENZYME BY BLOCKING PEROXIDES AND FREE RADICALS
SHIFT FROM EUMELANIN (DARKER) TO PHEOMELANIN (LIGHTER) NEW PRODUCTION
SKIN LIGHTENING

13. SKIN LIGHTENING MECHANISM OF ACTION: CYSTEINE
FURTHER SHIFT FROM EUMELANIN (DARKER) TO PHEOMELANIN (LIGHTER)
SKIN LIGHTENING

14. INHIBITION OF TYROSINASE ENZYME
MECHANISM OF ACTION: GLUTATHIONE AND CYSTEINE
INHIBITION OF TYROSINASE ENZYME
LESS EUMELANIN

15. SHIFT FROM EUMELANIN TO PHEOMELANIN
MECHANISM OF ACTION: GLUTATHIONE AND CYSTEINE
MORE PHEOMELANIN
SHIFT FROM EUMELANIN TO PHEOMELANIN
LESS EUMELANIN

16. Thus LESS darker melanin (Eumelanin)
MECHANISM OF ACTION: GLUTATHIONE AND CYSTEINE
Thus
LESS darker melanin (Eumelanin)
MORE lighter melanin (Pheomelanin)
lightening effect
MORE PHEOMELANIN
LESS EUMELANIN

17. In Vivo Test

18. INSTRUMENTAL EVALUATION
Cream with Kalilight (3% KALILIGHT)
Comparison Cream (CC)
(3% LIGHTENING ACTIVES) Vs
Instrumentation : Chroma Meter CR 400 Minolta
Test Duration : 6 weeks (2 times/day)
# of volunteers : 24 - from 30 to 70 y.o.
TEST:
1 - Skin brightness [L]
2 - Blue-yellow coloration [b*]
3 - Individual Tipology Angle [ITA°] f (L,b*)
4 - UV scan
5 - Photographic evaluation

19. Significant increase of Skin Brightness (L)
L = 0 (= black) 100 (= white) L 60 62
T = 0
T = 6 week
T = 0
T = 6 week
Kalilight
+ 2,2% CC
+ 2,3%
Significant increase of Skin Brightness (L)

20. 2 - BLUE-YELLOW COLORATION
B* = OLIVE-COLOR GRADUATION OF THE SKIN 18 17
T = 0
T = 6 week
T = 6 week
T = 0 b*
Significant decrease of B-Y (b*), much better than CC CC
- 0,2%
Kalilight
- 4,3%

21. 3 - INDIVIDUAL TIPOLOGY ANGLE
More ITA° = more lightning efficacy (0-360°) 30 35
ITA° =
T = 0
T = 6 week
T = 0
T = 6 week
Significant increase of ITA° CC
+ 3,3%
Kalilight
+ 4,2%

22. 4 -UV SCAN EVALUATION
The skin spots became lighter

23. 5 - PHOTOGRAPHIC EVALUATION
The skin spots became lighter Skin is more homogeneous

24. ANTIAGE PRODUCTS & BB CREAMS
CONCLUSION
NEW DE-PIGMENTING COMPLEX with MULTI-FUNCTIONAL effects
HOMOGENEUS COLORATION
SUN CARE APPLICATION
SHIFTING of
MELANIN SYNTHESIS
SPOT TREATMENT
INCREASE of CUTANEUS BRIGTHNESS
SPOT TREATMENT
“SOFT FOCUS”
ANTIAGE PRODUCTS & BB CREAMS

25. BRIGHTENING ANTI-AGING
NEW
ingredient
FACE CARE
MULTIFUNCTIONAL
PHYSIOLOGICAL
SAFE & VERY EFFECTIVE
BRIGHTENING ANTI-AGING
LIGHTENING

26. Via Pastore 1 - 25082 (Brescia) Italy
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Via Pastore (Brescia) Italy
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