2. Chemotherapy-Induced Cardiomyopathy
Monica Abraham
Intern Mentor
Atholton High School
Mentor:
Lili Barouch, M.D.
Johns Hopkins Cardiology
Columbia Medical Campus

3. Preview Research Question Anthracyclines
Chemotherapy-Induced Cardiomyopathy
Risk Factors
My Research
Conclusion

4. Research Question
Which risk factor makes patients most likely to develop chemotherapy-induced cardiomyopathy? Research Design: Causal-Comparative
Terms:
-chemotherapy: the treatment of cancer by the use of chemical substances
-cardiomyopathy: the deterioration of the heart muscle
-anthracycline: common type of breast cancer chemotherapy drug
-myocyte: muscle cell

5. Anthracyclines Chemotherapy agents
Commonly treat breast cancer and lymphomas
Can cause cardiomyopathy
Myocyte damage
Production of toxic radicals
Increase in oxidative stress
Lipid peroxidation
Vacuolation
Myocyte replacement by fibrous tissue

6. Chemotherapy-Induced Cardiomyopathy
Symptoms
palpitations, shortness of breath, chest pain, fatigue
Acute Cardiovascular Complications
Short-term
Arrythmias
Chronic Cardiotoxicity
Clinical heart failure
May be a link between acute and chronic cardiotoxicity

7. Risk Factors Cumulative dose Age Other cardiotoxic chemotherapy agents
Radiation
History of CVD

8. My Research Purpose is to identify most prevalent risk factor
Review charts of prior and current patients of Dr. Barouch to study patients’ histories
Be able to ascertain most common risk factor
Patients with that risk factor can then consider their options

9. Conclusion
Certain chemotherapy drugs, such as anthracyclines, damage myocardial function
Cardiomyopathy can result
Important to determine which risk factors are most detrimental
Prevention medication and screening can help reduce risk of cardiomyopathy

10. Works Cited Barouch, Lili. Personal interview. 23 Oct. 2013.
Gharib, M. I., and A. K. Burnett. "Chemotherapy-induced Cardiotoxicity: Current Practice and Prospects of Prophylaxis." European Journal of Heart Failure (2002). Oxford Journals. Web. 19 Oct
Hare, Joshua M. "The Etiologic Basis of Congestive Heart Failure." Atlas of Heart Failure: Cardiac Function and Dysfunction. 3rd ed Print.
Katz, Arnold M. "Molecular and Cellular Basis of Contraction." Atlas of Heart Failure: Cardiac Function and Dysfunction. Ed. Wilson S. Colucci. 3rd ed Print.
Singal, Pawan K., and Natasha Iliskovic. "Doxorubicin-Induced Cardiomyopathy." New England Journal of Medicine (1998). Google Scholar. Web. 19 Oct