1. Template provided by: “posters4research.com” Levels of fasting blood glucose (p<0.0001), Glycosylated hemoglobin (p<0.0001), triglycerides (p<0.001) were significantly raised and HDL cholesterol (p<0.001) was significantly decreased in patients of diabetes without complications when compared with controls. In patients with complications the levels of fasting blood glucose (p<0.0001), glycosylated hemoglobin (p<0.0001), total cholesterol (p<0.001), triglycerides (p<0.001), low density lipoprotein cholesterol (p<0.001), were significantly and High density lipoprotein cholesterol (p<0.0001), was significantly decreased. There is positive correlation with Glycosylated hemoglobin and levels of total cholesterol, triglycerides, and low density lipoprotein cholesterol in both the study groups. Whereas High density lipoprotein cholesterol shown negative correlation with increased glycosylated hemoglobin. CONCLUSION REFERENCES N.M. Naseb 2, J.R. Peela 1, S. Shakila 1, A.R. Said 1, L.T. Peela 4, R.N. Yedla 3 AM Jarari 2 S. D. Kolla 3,, L. T. Peela 4,, S. J. Dhoipode 5 1.Department of Biochemistry, Faculty of Medicine,University of Benghazi, Benghazi, Libya. 2. 2. Department of Biochemistry,Faculty of Medicine,Quest International University Perak, Ipoh, Malaysia, 3. Department of Biochemistry,Rangaraya Medical College,, Kakinada, India, 4. Great Eastern Medical School, Srikakulam, India 5. Department of Pharmacology, Guardian college of Dental Sciences and research centre,Ambernath,Thane,Maharastra,India. CORRELATION BETWEEN GLYCATED HEMOGLOBIN AND SERUM LIPIDS IN TYPE 2 DIABETICS IN EASTERN LIBYA. Logo Here There are 60 subjects has been chosen for study, out of 20 healthy controls, 40 subjects were diagnosed as diabetes with and without complications 20 patients each respectively. All the patients were measured Fasting blood glucose, glycosylated hemoglobin, serum cholesterol, Triacylglycerols and HDL cholesterol by using authenticated methods available. LDL cholesterol was measured calculation by using friedwal’s formula. MATERIALS AND METHODS MATERIALS AND METHODS RESULTS Bennett, S. and Magnus, P., (1994): Trends in cardiovascular risk factors in Australia. Results from the national heart foundation's risk factor. Med. J. Aust., 161: 519-527. Bisse' E, Abraham EC.,(1985): New less temperature- sensitive micro chromatographic method for the separation and quantization of glycosylated hemoglobin's using a non-cyanide buffer system Chromatog ; 344:81-91. Bunn, F.H. and Franklin, E. (1990): Elevation of glycated hemoglobin in diabetic patients. Diabetes, 30: 613-619 David B. Sacks, David E. Bruns, David E., and Marian Parrott. (2002): Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Clinical Chemistry.;48:436-472. Diagnosis and classification of diabetes mellitus.(2008): Diabetes Care.;1:S55-S60. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29 Suppl 1:S43–S48. [PubMed: 16373932] 2) American College of Obstetricians and. Diabetes Care. 2006;29:S4-S42. Diabetes Care, 34(Suppl 1): S11-S61. U.S. Department of Health and... diabetes.webmd.com/tc/type-2-diabetes- references. American Diabetes Association (2011). Standards of medical care in diabetes - 2011. Hoelzel, W., and Miedema, K., (1996): Development of a reference system for the international standardization of HbA1C/ glycohemoglobin determinations. J Int Fed Clin Chem.;9:62–67. Nalto K., (1984): High density lipoprotein (HDL) cholesterol. Clin. Chem. The C.V. Mosty Co. St Louls. Toronto. Princeton;1207 – 1213 and 37. Sparrow, CP; Olszewski, J (1993 Jul). "Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions". Journal of lipid research 34 (7): 1219–28. PMID 8103788. PMID8103788 Tertove, V.V., Kaplun, V.V. and Orekhov, A.N., (1995): Apolipoprotein B-bound as a marker for evaluation of low density lipoprotein oxidation in vivo. Clin. Chem., 6: 24-27. Conclusion: According to the above results and correlation between glycosylated hemoglobin and serum lipids it is strongly suggesting dyslipidemias are common in diabetic patients when it is not controlled. Measurement of glycosylated hemoglobin is more useful than fasting blood glucose for control of diabetes and its complications. Table.1 Controls Table.2 Diabetics without complications Table.3 Diabetics with complications FBSHbA1cTCLDLHDLTGs Mean 90.75.64124.6570.7046.15136.60 STD ± 13.85± 1.66± 29.16± 29.68± 18.58± 39.83 FBSHbA1cTCLDLHDLTGs Mean 158.959.23150.267.9035.65163.6 STD ± 39.99± 2.26± 52.62± 42.18± 8.66± 82.25 t-test -7.298- 6.720-1.8250.2232.44-1.162 p- Value < 0.0001 0.0840.826 < 0.001 signifi cance H.S FBSHbA1cTCLDLHDLTGs Mean 191.858.86171.2106.3028.10162.7 STD ± 56.053 ± 1.62 ± 47.246 ± 39.45± 5.37± 59.54 t-test -7.657- 5.459- 3.733-3.9384.129-3.291 p- Value < 0.0001 < 0.001 Signifi cance H.S Prevalence of diabetes mellitus is a global problem and Libya is no exception to this problem mainly due to raised incidence of metabolic syndrome, genetic predisposition and dietary habits. Complications of diabetes includes renal, ophthalmic and vascular complications particularly atherosclerosis are common. Present study is the status of serum lipids and lipoproteins in patients with and without complications in correlation with HbA1c. INTRODUCTION INTRODUCTION