1. MCQ – I V INDUCTION AGENTS

2. For intravenous anaesthetic agents:
FFTTT
a) the end point of induction of anaesthesia is loss of the eyelash reflex b) the clearance is their rate of excretion c) lower doses will be required for induction in hypovolaemic patients d) the effects on the CNS. depend on their degree of ionisation e) their non-protein bound fraction increase in liver and renal diseases

3. Factors which affect the peak effect of intravenous anaesthetics include:
TFFTT
a) dose administered b) volume of distribution c) hepatic clearance d) rate of injection e) cardiac output

4. Midazolam:
TTTTT
a) has a half-life of less than 2 hours b) is water soluble at a pH 4 c) has an active metabolite d) can have a prolonged effect if given with erythromycin e) can be given by the intranasal route

5. Midazolam:
TTFTT
a) is an anticonvulsant b) is lipid soluble at physiological pH c) has no active metabolites d) has an elimination half-life of 2-4 hours e) can be administered as nasal drops for premedication  

6. Ketamine:
TTTFT
a) raises the plasma noradrenaline level b) can cause unpleasant side-effects in adults for 24 hours after administration c) is a depressant to denervated cardiac muscle d) produces a loss of consciousness in one arm-brain circulation time e) is a bronchdilator

7. Ketamine:
FFFFF
a) is an imidazole derivative b) has also antanalgesic effect c) is contraindicated rectally d) has no active metabolites e) probably has no effect on intracranial pressure

8. Ketamine:
TFTTT
a) has marked analgesic properties mediated by its binding to NMDA receptors b) causes a fall in cardiac output and a rise in heart rate c) is contraindicated in patients with raised intracerebral pressure d) has active metabolites e) causes postoperative dreaming and hallucinations which are less frequent in children

9. S(+) ketamine compared with R(-) ketamine:
TTTTT
a) is 3-4 times more potent b) is associated with less incidence of emergence reaction c) is a better analgesic d) has a faster recovery e) has a higher affinity for NMDA receptors

10. Methohexitone:
TTTFF
a) is an oxybarbiturate b) may cause pain on injection c) is a methylated hexobarbitone d) is safer in asthma than thiopentone e) has a shorter half life than propofol

11. Propofol:  
FTTFT
a) has a pH of 7.0 b) is insoluble in water c) is twice as potent as thiopentone d) can be given as an infusion because its terminal half-life is less than 30 minutes e) may change the colour of urine due to propofol glucuronide  

12. Propofol:
TTTTT
a) is insoluble in water b) is bound to albumin up to 97-98% c) reduces sodium channel opening times in neuronal membranes d) is isotonic e) does not cause tachycardia

13. Thiopentone causes a decrease in BP by : A
Thiopentone causes a decrease in BP by : A. Direct decrease in myocardial contractility B. Fall in systemic vascular resistance C. Decrease in venous tone
Thiopentone: A. Is the sulphur analogue of phenobarbitone B. Has higher protein binding than its oxy analogue C. ? 6% sodium bicarbonate D. Isotonic at 2.5% concentration

14. Methohexitone: A. Has a molecular weight of 285 B
Methohexitone: A. Has a molecular weight of 285 B. Has a melting point of 158 degrees C. A 2.5% solution is isotonic D. Is yellow