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PAPULOSQUAMOUS DISEASES Psoriasis Psoriasis Lichen planus Lichen planus Lichen nitidus Lichen nitidus Pityriasis rosea Pityriasis rosea Pityriasis rubra pilaris Pityriasis rubra pilaris Seborrheic dermatitis Seborrheic dermatitis Pityriasis lichenoides et varioliformis acuta Pityriasis lichenoides et varioliformis acuta Parapsoriasis Parapsoriasis
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PAPULOSQUAMOUS DISEASES (II) Psoriasis Psoriasis Seborrheic dermatitis Seborrheic dermatitis
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PSORIASIS Psoriasis is a common, genetically determined, inflammatory and hyperproliferative skin disease. Psoriasis is a hereditary disorder of skin with several clinical expressions. The most frequent type is psoriasis vulgaris, which occurs as chronic, recurring, scaling papules and plaques.
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CLASSIFICATION Psoriasis vulgaris Psoriasis vulgaris –Acute guttate –Chronic plaque –Inverse –Palmoplantar Psoriatic erythroderma Psoriatic erythroderma Pustular psoriasis Pustular psoriasis Psoriatic arthritis Psoriatic arthritis
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PSORIASIS VULGARIS
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Epidemiology Age of onset: May begin at any age. Uncommon < 10 years. Early: Peak incidence at 22.5 years of age (in children the mean age of onset is 8 years). Late: About age 55. Age of onset: May begin at any age. Uncommon < 10 years. Early: Peak incidence at 22.5 years of age (in children the mean age of onset is 8 years). Late: About age 55. Sex: Equal incidence. Sex: Equal incidence. Race: Low incidence in West Africans, Japanese; very low incidence or absence in North and South American Indians. Race: Low incidence in West Africans, Japanese; very low incidence or absence in North and South American Indians. Heredity: Polygenic trait. HLA-B13, B17, Bw57, HLA-Cw6 ( aerlier age of onset and with a positive family history) Heredity: Polygenic trait. HLA-B13, B17, Bw57, HLA-Cw6 ( aerlier age of onset and with a positive family history) Triggering Factors: Physical trauma (Koebner’s phenomenon), infections (acute streptococcal), stress, drugs ( glucocorticoids, lithium, antimalarials, interferon, beta-adrenergic blockers), heavy alcohol, smoking Triggering Factors: Physical trauma (Koebner’s phenomenon), infections (acute streptococcal), stress, drugs ( glucocorticoids, lithium, antimalarials, interferon, beta-adrenergic blockers), heavy alcohol, smoking Comorbid disease: Psoriatic arthritis, Crohn’s disease, cancer, depression, non-alcoholic fatty liver disease, metabolic syndrome (or components of it), cardiovascular disorders. Comorbid disease: Psoriatic arthritis, Crohn’s disease, cancer, depression, non-alcoholic fatty liver disease, metabolic syndrome (or components of it), cardiovascular disorders.
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Pathogenesis A chronic inflammatory disorder with polygenic predisposition combined with triggering environmental factors such as trauma,infection, or medication. A chronic inflammatory disorder with polygenic predisposition combined with triggering environmental factors such as trauma,infection, or medication. Psoriasis is a T-lymphocyte-mediated autoimmune disease (mixed Th1 and Th17 disease). T cells and cytokines play a pivotale role ( overexpression of type 1 cytokines like IL-1, IL-6, IL-8, IL-12, IFN gamma and TNF alpha ) Psoriasis is a T-lymphocyte-mediated autoimmune disease (mixed Th1 and Th17 disease). T cells and cytokines play a pivotale role ( overexpression of type 1 cytokines like IL-1, IL-6, IL-8, IL-12, IFN gamma and TNF alpha ) The underlying pathophysiology involves epidermal proliferation and differentiation, angiogenesis and the cellular immune system. The underlying pathophysiology involves epidermal proliferation and differentiation, angiogenesis and the cellular immune system. Dysregulated interactions of innate and adaptive components of the immune system with resident cutaneous cell types. Dysregulated interactions of innate and adaptive components of the immune system with resident cutaneous cell types. 1) Cross-talk between innate (macrophages, mast cells, granulocytes) and adaptive immunity( Tcells) 1) Cross-talk between innate (macrophages, mast cells, granulocytes) and adaptive immunity( Tcells) 2) Interleukin-23 / Th 17 axis 3) Effect on resident T cells of the skin (antimicrobial peptides, cytokines and chemokines secreted by keratinocytes act as chemoattractants for infiltrating immune cells) 4)Effect on vascular endothelial cells ( the inflammatory milieu leads to induction and activation of a range of pro-angiogenic factors – VEGF -, TNF alpha-governed pro- inflammatory environment in psoriatic skin induces endothelial adhesion molecules which facilitate the recruitement of circulating leucocytes in psoriatic skin.
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Physical examination Acute Guttate Type: Eruption of small salmon-pink papules (guttate: Latin gutta, “drop”), with or without scales, disseminated, generalized, mainly on the upper trunk, strongly associated with streptococcal throat infection, frequent in young adults and children Acute Guttate Type: Eruption of small salmon-pink papules (guttate: Latin gutta, “drop”), with or without scales, disseminated, generalized, mainly on the upper trunk, strongly associated with streptococcal throat infection, frequent in young adults and children Chronic Stable (plaque) Type: Sharply marginated, dull-red plaques with loosely adherent, lamelar, silvery-white scales. Single lesion or lesions localized to one or more predilection sites: elbows, knees, sacral-gluteal region, scalp, plm/soles. Sometimes only regional involvement(scalp), often generalized. Chronic Stable (plaque) Type: Sharply marginated, dull-red plaques with loosely adherent, lamelar, silvery-white scales. Single lesion or lesions localized to one or more predilection sites: elbows, knees, sacral-gluteal region, scalp, plm/soles. Sometimes only regional involvement(scalp), often generalized. Special Sites Special Sites –Palms and Soles –Scalp –Inverse Psoriasis (perianal, genital and body folds) –Nails: pitting, subungual hyperkeratosis, onycholysis, the oil spot (pathognomonic)
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Laboratory examinations Dermatopathology Dermatopathology Culture: Throat culture Culture: Throat culture
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Palmoplantar psoriasis Chronic, relapsing eruption limited to palms and soles. Numerous very typical sterile, yellow, deep- seated pustules that evolve into dusky-red crusts. Chronic, relapsing eruption limited to palms and soles. Numerous very typical sterile, yellow, deep- seated pustules that evolve into dusky-red crusts. Incidence: Low as compared to psoriasis vulgaris Incidence: Low as compared to psoriasis vulgaris Age of onset: 50 to 60 years. More common in females (4:1) Age of onset: 50 to 60 years. More common in females (4:1) Symptoms: Stinging, burning, itching. Eruptions come and go, in waves. Symptoms: Stinging, burning, itching. Eruptions come and go, in waves. Differential diagnosis: Tinea manus, tinea pedis, dyshidrotic eczema, contact dermatitis, HSV infection. Differential diagnosis: Tinea manus, tinea pedis, dyshidrotic eczema, contact dermatitis, HSV infection. Course: Persistent for years and characterized by unexplained remissions and exacerbations. Course: Persistent for years and characterized by unexplained remissions and exacerbations.
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Generalized acute pustular psoriasis (Von Zumbusch) This disorder can be a life-threatening medical problem with an abrupt onset. It starts with a burning fiery-red diffuse erythema that spreads in hours with pinpoint pustules appearing in clusters. Fever, weakness, severe malaise, fast pulse, leukocytosis, shedding of nails, hair loss, skin tenderness This disorder can be a life-threatening medical problem with an abrupt onset. It starts with a burning fiery-red diffuse erythema that spreads in hours with pinpoint pustules appearing in clusters. Fever, weakness, severe malaise, fast pulse, leukocytosis, shedding of nails, hair loss, skin tenderness Special types: Impetigo herpetiformis, acrodermatitis continua of Hallopeau Special types: Impetigo herpetiformis, acrodermatitis continua of Hallopeau
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Psoriatic arthritis Rare before age 20 Rare before age 20 Sero(-), “distal”, asymmetric oligoarthritis Sero(-), “distal”, asymmetric oligoarthritis Mutilating arthritis (bone erosion, osteolysis or ankylosis. Mutilating arthritis (bone erosion, osteolysis or ankylosis. “Axial” (sacroiliac, hip, cervical) “Axial” (sacroiliac, hip, cervical) Dactylitis (sausage fingers) Dactylitis (sausage fingers) May be present (in 10% of patients) without any visible psoriasis May be present (in 10% of patients) without any visible psoriasis Often psoriatic involvement of fingertips and periungual skin Often psoriatic involvement of fingertips and periungual skin Massive nail involvement by psoriasis is frequent Massive nail involvement by psoriasis is frequent
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Management (1) Factors influencing selection of treatment: Factors influencing selection of treatment: –Age –Type of psoriasis –Site and extent of involvement –Previous treatment –Associated medical disorders
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Management (2) Localized psoriasis Localized psoriasis –Topical glucocorticoids –Intralesional triamcinolone acetonide –Topical anthralin –Topical vitamin D analogues( calcipotriene, 0.005%, ointment and cream) –Topical tacrolimus, 0.1% –Tazarotene ( a topical retinoid, 0.05 and 0.1% gel ) –Topical dithranol and coal tar –Topical PUVA, UVB –Salicylic acid –Moisturizing
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Management (3) Generalized psoriasis Generalized psoriasis –Narrow-Band UVB Phototherapy –Oral PUVA Photochemotherapy –Oral Retinoids –Methotrexate –Cyclosporine –Diet –Monoclonal Antibodies and Fusion Proteins: Infliximab, Etanercept, Adalimumab, Ustekinumab (IL- 12/23)
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GEOGRAPHIC TONGUE Also known as benign migratory glossitis The condition usually presents as asymptomatic erythematous patches with serpiginous borders, resembling a map. These lesions characteristically have a migratory nature.
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RELATED PHYSICAL FINDINGS NAIL CHANGES IN PSORIASIS.
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Generalized Pustular Psoriasis is a distinctive characterized by acute variant of psoriasis. Attacks are fever that lasts several days and a sudden generalized eruption of sterile pustules 2–3 mm in diameter. The pustules are disseminated over the trunk and extremities, including the nail beds, palms, and soles. The pustules usually arise on highly erythematous skin, first as patches and then becoming confluent as the disease becomes more severe.
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ERYTHRODERMIC PSORIASIS generalized form of the disease that affects all body sites, including the face, hands, feet, nails, trunk, and extremities Erythema is the most prominent feature, and scaling is different Instead of thick, adherent, white scale there is superficial scaling. Psoriatic skin is often hypohidrotic due to occlusion of the sweat ducts
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INVERSE (FLEXURAL) PSORIASIS lesions may be localized in the major skin folds, such as the axillae, the genito-crural region, and the neck. lesions may be localized in the major skin folds, such as the axillae, the genito-crural region, and the neck. Scaling is usually minimal or absent, and the lesions show a glossy sharply demarcated erythema, which is often localized to areas of skin-to-skin contact. Scaling is usually minimal or absent, and the lesions show a glossy sharply demarcated erythema, which is often localized to areas of skin-to-skin contact. Sweating is impaired in affected areas. Sweating is impaired in affected areas.
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SEBORRHEİC DERMATİTİS SD is a very common chronic dermatosis characterized by redness and scaling and occuring in regions where the sebaceous glands are most active, such as the face and scalp, the presternal area, and the body folds.
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EPIDEMIOLOGY AND ETIOLOGY Age of Onset: Infancy (within the first months), puberty, most between 20 and 50 years or older Age of Onset: Infancy (within the first months), puberty, most between 20 and 50 years or older Infantile SD: Usually begins about one week after birth and may persist for several months Infantile SD: Usually begins about one week after birth and may persist for several months Adult SD: Chronic relapsing course; dandruff ( pityriasis capitis simplex), non-purulent otitis externa, intertrigo Adult SD: Chronic relapsing course; dandruff ( pityriasis capitis simplex), non-purulent otitis externa, intertrigo Sex: More common in males Sex: More common in males Predisposing and Exacerbating Factors: Hereditary diathesis, parkinson’s disease, some neuroleptic drugs, emotional stress, HIV disease Predisposing and Exacerbating Factors: Hereditary diathesis, parkinson’s disease, some neuroleptic drugs, emotional stress, HIV disease
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PATHOGENESİS 1) Immune responses to Malassezia furfur (P.ovale): Part of the normal resident skin flora. Studies on the cellular immunity have yielded contradictory results. The inflammation may be irritant ? caused by toxic metabolites, lipase and reactive oxygen species. 1) Immune responses to Malassezia furfur (P.ovale): Part of the normal resident skin flora. Studies on the cellular immunity have yielded contradictory results. The inflammation may be irritant ? caused by toxic metabolites, lipase and reactive oxygen species. 2) Active sebaceous glands: Often associated with sebum overproduction. 2) Active sebaceous glands: Often associated with sebum overproduction. 3) Abnormal composition of the skin surface lipids ( increased triglycerides and cholesterol, decreased squalene and FFA ) and imbalance of the microbial flora 3) Abnormal composition of the skin surface lipids ( increased triglycerides and cholesterol, decreased squalene and FFA ) and imbalance of the microbial flora
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HİSTORY AND SKİN LESİONS Gradual onset Gradual onset Seasonal variations: Worse in winter, sunlight ( dual effect) Seasonal variations: Worse in winter, sunlight ( dual effect) Pruritus is variable, often increased by perspiration Pruritus is variable, often increased by perspiration Hairy areas of head, face, trunk, body folds, genitalia Hairy areas of head, face, trunk, body folds, genitalia
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COURSE AND PROGNOSIS The condition improves in the summer and flares in the fall. The condition improves in the summer and flares in the fall. Recurrences and remissions Recurrences and remissions Infantile and adolescent SD disappears with age. Infantile and adolescent SD disappears with age. Differential diagnosis: Atopic dermatitis, irritant diaper dermatitis, psoriasis, langerhans-cell hystiocytosis, Leiners’ disease, Wiskott Aldrich syndrome Differential diagnosis: Atopic dermatitis, irritant diaper dermatitis, psoriasis, langerhans-cell hystiocytosis, Leiners’ disease, Wiskott Aldrich syndrome
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MANAGEMENT This chronic disorder requires initial therapy followed by chronic maintenance therapy This chronic disorder requires initial therapy followed by chronic maintenance therapy Initial topical therapy: Glucocorticoid cream or lotion, ketoconazole cream, pimecrolimus cream, tacrolimus ointment, medicated shampoos (selenium sulfide, zinc pyrithione, ketoconazole, tar) Initial topical therapy: Glucocorticoid cream or lotion, ketoconazole cream, pimecrolimus cream, tacrolimus ointment, medicated shampoos (selenium sulfide, zinc pyrithione, ketoconazole, tar) Systemic therapy: Itraconazole, fluconazole Systemic therapy: Itraconazole, fluconazole Maintenance therapy Maintenance therapy
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