6. 1.Label the feedback type 2.Identify the input 3.Identify the physiological process 4. Describe how the system is responding to the input. 5. Identify the output

7. Big Ideas 1.B.1: Organisms share many conserved core processes and features that evolved and are widely distributed among organisms today. –Cell structure (neurons); see figure 48.4 © 2011 Pearson Education, Inc.

8. Big Ideas 2.A.1: Organisms use free energy to maintain organization, grow, and reproduce (e.g. Krebs Cycle  ATP  solute pumps  nerve conduction; see Fig. 48.7, 48.11) 2.B.1: Cell membranes are selectively permeable due to their structure (e.g. Na+/K+ pumps) 2.B.2: Growth and dynamic homeostasis are maintained by the constant movement of molecules across membranes (e.g. membrane proteins play a role in facilitated diffusion of charged, polar molecules [Na+/K+ pumps]) © 2011 Pearson Education, Inc.

9. Big Ideas 2.A.1: Organisms use free energy to maintain organization, grow, and reproduce (e.g. Krebs Cycle  ATP  solute pumps  nerve conduction) 2.B.1: Cell membranes are selectively permeable due to their structure (e.g. Na+/K+ pumps; see Fig. 48.7, 48.11) 2.B.2: Growth and dynamic homeostasis are maintained by the constant movement of molecules across membranes (e.g. membrane proteins play a role in facilitated diffusion of charged, polar molecules [Na+/K+ pumps]) © 2011 Pearson Education, Inc.

10. Big Ideas 2.A.1: Organisms use free energy to maintain organization, grow, and reproduce (e.g. Krebs Cycle  ATP  solute pumps  nerve conduction) 2.B.1: Cell membranes are selectively permeable due to their structure (e.g. Na+/K+ pumps) 2.B.2: Growth and dynamic homeostasis are maintained by the constant movement of molecules across membranes (e.g. membrane proteins play a role in facilitated diffusion of charged, polar molecules [Na+/K+ pumps]) © 2011 Pearson Education, Inc.

11. Big Ideas 2.D.3): Biological systems are affected by disruptions to their dynamic homeostasis (e.g. nerve toxins mimic, block NTs) © 2011 Pearson Education, Inc.

12. Big Ideas 3.D.2) Cell communication processes share common features that reflect a shared evolutionary history (e.g. EPSP/IPSP, NTs; see Fig. 48.17) 3.D.3) Signal transduction pathways link signal reception with cellular response (e.g. signal cascade & muscle contraction) 3.D.3) Changes in signal transduction pathways can alter cellular response (e.g. nerve toxins, poisons, pesticides) 3.E.2 a-c): Animals have nervous systems that detect external and internal signals, transmit and integrate information and produce responses. (see description in APCE) © 2011 Pearson Education, Inc.

13. Big Ideas 3.D.2) Cell communication processes share common features that reflect a shared evolutionary history (e.g. EPSP/IPSP, NTs) 3.D.3) Signal transduction pathways link signal reception with cellular response (e.g. signal cascade & muscle contraction; see Fig. 50.30) 3.D.3) Changes in signal transduction pathways can alter cellular response (e.g. nerve toxins, poisons, pesticides) 3.E.2 a-c): Animals have nervous systems that detect external and internal signals, transmit and integrate information and produce responses. (see description in APCE) © 2011 Pearson Education, Inc.

14. Big Ideas 3.D.2) Cell communication processes share common features that reflect a shared evolutionary history (e.g. EPSP/IPSP, NTs) 3.D.3) Signal transduction pathways link signal reception with cellular response (e.g. signal cascade & muscle contraction) 3.D.3) Changes in signal transduction pathways can alter cellular response (e.g. nerve toxins, poisons, pesticides) 3.E.2 a-c): Animals have nervous systems that detect external and internal signals, transmit and integrate information and produce responses. (see description in APCE) © 2011 Pearson Education, Inc.

15. Big Ideas 3.D.2) Cell communication processes share common features that reflect a shared evolutionary history (e.g. EPSP/IPSP, NTs) 3.D.3) Signal transduction pathways link signal reception with cellular response (e.g. signal cascade & muscle contraction) 3.D.3) Changes in signal transduction pathways can alter cellular response (e.g. nerve toxins, poisons, pesticides) 3.E.2 a-c): Animals have nervous systems that detect external and internal signals, transmit and integrate information and produce responses. (see APCE; know how neuromuscular system causes contraction of muscle) © 2011 Pearson Education, Inc.

16. Big Ideas 4.A.4 a): Organisms exhibit complex properties due to interactions between their constituent parts (e.g. muscle & skeletal/nervous systems) 4.A.4 b): Interactions and coordination between systems provide essential biological activities (e.g. muscle & skeletal/nervous systems) 4.B.1 b-d): Interactions between molecules affect their structure and function (e.g. shape of ligands, receptors) 4.B.2 a.2): Within multicellular organisms, specialization of organs contributes to the overall functioning of the organism (e.g. communication & control) © 2011 Pearson Education, Inc.

17. Big Ideas 4.A.4 a): Organisms exhibit complex properties due to interactions between their constituent parts (e.g. muscle & skeletal/nervous systems) 4.A.4 b): Interactions and coordination between systems provide essential biological activities (e.g. muscle & skeletal/nervous systems; see Figure 50.31) 4.B.1 b-d): Interactions between molecules affect their structure and function (e.g. shape of ligands, receptors) 4.B.2 a.2): Within multicellular organisms, specialization of organs contributes to the overall functioning of the organism (e.g. communication & control) © 2011 Pearson Education, Inc.

18. Big Ideas 4.A.4 a): Organisms exhibit complex properties due to interactions between their constituent parts (e.g. muscle & skeletal/nervous systems) 4.A.4 b): Interactions and coordination between systems provide essential biological activities (e.g. muscle & skeletal/nervous systems) 4.B.1 b-d): Interactions between molecules affect their structure and function (e.g. shape of NTs as ligands, receptors  response of some kind) 4.B.2 a.2): Within multicellular organisms, specialization of organs contributes to the overall functioning of the organism (e.g. communication & control) © 2011 Pearson Education, Inc.

19. Big Ideas 4.A.4 a): Organisms exhibit complex properties due to interactions between their constituent parts (e.g. muscle & skeletal/nervous systems) 4.A.4 b): Interactions and coordination between systems provide essential biological activities (e.g. muscle & skeletal/nervous systems) 4.B.1 b-d): Interactions between molecules affect their structure and function (e.g. shape of ligands, receptors) 4.B.2 a.2): Within multicellular organisms, specialization of organs contributes to the overall functioning of the organism (e.g. communication & control) © 2011 Pearson Education, Inc.

20. Cell Signaling Supplement Packet (p.25)

21. Figure 48.1

22. Overview: Lines of Communication The cone snail kills prey with venom that disables neurons Neurons are nerve cells that transfer information within the body Neurons use two types of signals to communicate: –electrical signals (long-distance) –chemical signals (short-distance) © 2011 Pearson Education, Inc.

23. Interpreting signals in the nervous system involves sorting a complex set of paths and connections Processing of information takes place in either: –simple clusters of neurons called ganglia –or a more complex organization of neurons called a brain © 2011 Pearson Education, Inc.

24. Key Points Neurons are built and organized for information transfer Neurons are built and organized for information transfer Ion pumps and ion channels establish the resting potential of a neuron Action potentials are the signals conducted by axons Neurons communicate with other cells at synapses © 2011 Pearson Education, Inc.

25. Introduction to Information Processing Nervous systems process information in three stages: –sensory input –integration –motor output © 2011 Pearson Education, Inc.

26. Neurons are built and organized for information transfer Sensors detect external stimuli and internal conditions and transmit information along sensory neurons Sensory information is sent to the brain or ganglia, where interneurons integrate the information Motor output leaves the brain or ganglia via motor neurons, which trigger muscle or gland activity © 2011 Pearson Education, Inc.

27. Figure 48.3 Sensor Effector Sensory input Motor output Integration Peripheral nervous system (PNS) Central nervous system (CNS)

28. Many animals have a complex nervous system that consists of –A central nervous system (CNS) where integration takes place; this includes the brain and a nerve cord –A peripheral nervous system (PNS), which carries information into and out of the CNS –The neurons of the PNS, when bundled together, form nerves © 2011 Pearson Education, Inc.

29. Neuron Structure and Function Most of a neuron’s organelles are in the cell body Dendrites: (Input) highly branched extensions that receive signals from other neurons Axon: (output) typically a much longer extension that transmits signals to other cells at synapses Axon hillock: The cone-shaped base of an axon © 2011 Pearson Education, Inc.

30. Figure 48.4 Nucleus Dendrites Stimulus Axon hillock Cell body Presynaptic cell Signal direction Axon Synapse Neurotransmitter Synaptic terminals Postsynaptic cell Synaptic terminals

31. Synaptic terminal: where one axon passes information across the synapse in the form of chemical messengers called neurotransmitters Synapse: junction between an axon and another cell © 2011 Pearson Education, Inc.

32. Figure 48.4 Nucleus Dendrites Stimulus Axon hillock Cell body Presynaptic cell Signal direction Axon Synapse Neurotransmitter Synaptic terminals Postsynaptic cell Synaptic terminals

33. Information is transmitted from a presynaptic cell (a neuron) to a postsynaptic cell (a neuron, muscle, or gland cell) Most neurons are nourished or insulated by cells called glia © 2011 Pearson Education, Inc.

34. Dendrites Axon Cell body Portion of axon Sensory neuronInterneurons Motor neuron Figure 48.5

35. Figure 48.6 Glia 80  m Cell bodies of neurons

36. Key Points Neurons are built and organized for information transfer Ion pumps and ion channels establish the resting potential of a neuron Ion pumps and ion channels establish the resting potential of a neuron Action potentials are the signals conducted by axons Neurons communicate with other cells at synapses © 2011 Pearson Education, Inc.

37. Table 48.1

39. Ion pumps and ion channels establish the resting potential of a neuron Every cell has a voltage (difference in electrical charge) across its plasma membrane called a membrane potential The resting potential is the membrane potential of a neuron not sending signals Changes in membrane potential act as signals, transmitting and processing information © 2011 Pearson Education, Inc.

40. Formation of the Resting Potential In a mammalian neuron at resting potential, the concentration of K + is highest inside the cell, while the concentration of Na + is highest outside the cell Sodium-potassium pumps use the energy of ATP to maintain these K + and Na + gradients across the plasma membrane These concentration gradients represent chemical potential energy © 2011 Pearson Education, Inc.

41. The opening of ion channels in the plasma membrane converts chemical potential to electrical potential A neuron at resting potential contains many open K + channels and fewer open Na + channels; K + diffuses out of the cell The resulting buildup of negative charge within the neuron is the major source of membrane potential © 2011 Pearson Education, Inc.

42. Key Na  KK Sodium- potassium pump Potassium channel Sodium channel OUTSIDE OF CELL INSIDE OF CELL Figure 48.7

43. In a resting neuron, the currents of K + and Na + are equal and opposite, and the resting potential across the membrane remains steady © 2011 Pearson Education, Inc.

44. Key Points Neurons are built and organized for information transfer Ion pumps and ion channels establish the resting potential of a neuron Action potentials are the signals conducted by axons Action potentials are the signals conducted by axons Neurons communicate with other cells at synapses © 2011 Pearson Education, Inc.

45. Action potentials are the signals conducted by axons Changes in membrane potential occur because neurons contain gated ion channels that open or close in response to stimuli © 2011 Pearson Education, Inc.

46. Figure 48.9 Microelectrode Voltage recorder Reference electrode TECHNIQUE

47. When gated K + channels open, K + diffuses out, making the inside of the cell more negative This is hyperpolarization, an increase in magnitude of the membrane potential © 2011 Pearson Education, Inc. Hyperpolarization and Depolarization

48. Stimulus Threshold Resting potential Hyperpolarizations Time (msec)  50 0  50  100 10 2 345  50 0  50  100  50 0  50  100 Time (msec) 10 2 345 10 2 345 6 Threshold Resting potential Threshold Resting potential Stimulus Strong depolarizing stimulus Action potential Depolarizations Membrane potential (mV) (a) Graded hyperpolarizations produced by two stimuli that increase membrane permeability to K  (b) Graded hyperpolarizations produced by two stimuli that increase membrane permeability to Na  (c) Action potential triggered by a depolarization that reaches the threshold Figure 48.10

49. Stimulus Threshold Resting potential Hyperpolarizations Time (msec)  50 0  50  100 1 0 2 3 4 5 Membrane potential (mV) (a) Graded hyperpolarizations produced by two stimuli that increase membrane permeability to K  Figure 48.10a

50. Opening other types of ion channels triggers a depolarization, a reduction in the magnitude of the membrane potential (making the cell more positive) For example, depolarization occurs if gated Na + channels open and Na + diffuses into the cell © 2011 Pearson Education, Inc.

51. Stimulus Threshold Resting potential Depolarizations Time (msec)  50 0  50  100 1 0 2 345 Membrane potential (mV) (b) Graded depolarizations produced by two stimuli that increase membrane permeability to Na  Figure 48.10b

52. Graded potentials are changes in polarization where the magnitude of the change varies with the strength of the stimulus These are not the nerve signals that travel along axons, but they do have an effect on the generation of nerve signals © 2011 Pearson Education, Inc. Graded Potentials and Action Potentials

53. If a depolarization shifts the membrane potential sufficiently, it results in a massive change in membrane voltage called an action potential Action potentials have a constant magnitude, are all-or-none, and transmit signals over long distances They arise because some ion channels are voltage-gated, opening or closing when the membrane potential passes a certain level © 2011 Pearson Education, Inc.

54. Strong depolarizing stimulus Threshold Resting potential Time (msec)  50 0  50  100 1 0 2 3 4 5 Membrane potential (mV) 6 (c) Action potential triggered by a depolarization that reaches the threshold Action potential Figure 48.10c

55. Generation of Action Potentials: A Closer Look An action potential can be considered as a series of stages At resting potential 1.Most voltage-gated channels are closed o sodium (Na + ) and potassium (K + ) channels © 2011 Pearson Education, Inc.

56. OUTSIDE OF CELL INSIDE OF CELL Inactivation loop Sodium channel Potassium channel Threshold Resting potential Time Membrane potential (mV)  50  100  50 0 Na  KK Key 11 Resting state Figure 48.11-1

57. When an action potential is generated 2.Voltage-gated Na + channels open first and Na + flows into the cell 3.During the rising phase, the threshold is crossed, and the membrane potential increases 4.During the falling phase, voltage-gated Na + channels become inactivated; voltage-gated K + channels open, and K + flows out of the cell © 2011 Pearson Education, Inc.

58. OUTSIDE OF CELL INSIDE OF CELL Inactivation loop Sodium channel Potassium channel Threshold Resting potential Time Membrane potential (mV)  50  100  50 0 Na  KK Key 2112 Resting state Depolarization Figure 48.11-2

59. When an action potential is generated 2.Voltage-gated Na + channels open first and Na + flows into the cell 3.During the rising phase, the threshold is crossed, and the membrane potential increases 4.During the falling phase, voltage-gated Na + channels become inactivated; voltage-gated K + channels open, and K + flows out of the cell © 2011 Pearson Education, Inc.

60. OUTSIDE OF CELL INSIDE OF CELL Inactivation loop Sodium channel Potassium channel Action potential Threshold Resting potential Time Membrane potential (mV)  50  100  50 0 Na  KK Key 213123 Resting state Depolarization Rising phase of the action potential Figure 48.11-3

61. When an action potential is generated 2.Voltage-gated Na + channels open first and Na + flows into the cell 3.During the rising phase, the threshold is crossed, and the membrane potential increases 4.During the falling phase, voltage-gated Na + channels become inactivated; voltage-gated K + channels open, and K + flows out of the cell © 2011 Pearson Education, Inc.

62. OUTSIDE OF CELL INSIDE OF CELL Inactivation loop Sodium channel Potassium channel Action potential Threshold Resting potential Time Membrane potential (mV)  50  100  50 0 Na  KK Key 21341234 Resting state Depolarization Rising phase of the action potential Falling phase of the action potential Figure 48.11-4

63. 5. During the undershoot, membrane permeability to K + is at first higher than at rest, then voltage-gated K + channels close and resting potential is restored © 2011 Pearson Education, Inc.

64. OUTSIDE OF CELL INSIDE OF CELL Inactivation loop Sodium channel Potassium channel Action potential Threshold Resting potential Time Membrane potential (mV)  50  100  50 0 Na  KK Key 21345123451 Resting state Undershoot Depolarization Rising phase of the action potential Falling phase of the action potential Figure 48.11-5

65. Figure 48.11a c)_________________ b)___________ a)___________________ Time Membrane potential (mV)  50  100  50 0 123451 Question: What’s happening at each step with respect to influx (gain) and efflux (loss) of ions? What effect do these activities have on the membrane potential of the cell? Label a-c and describe events 1-5. Specifically talk about movement of Na +, K +.

66. Figure 48.11a Action potential Threshold Resting potential Time Membrane potential (mV)  50  100  50 0 123451

67. During the refractory period after an action potential, a second action potential cannot be initiated The refractory period is a result of a temporary inactivation of the Na + channels © 2011 Pearson Education, Inc.

69. Conduction of Action Potentials At the site where the action potential is generated, usually the axon hillock, an electrical current depolarizes the neighboring region of the axon membrane Action potentials travel in only one direction: toward the synaptic terminals © 2011 Pearson Education, Inc.

70. Inactivated Na + channels behind the zone of depolarization prevent the action potential from traveling backwards © 2011 Pearson Education, Inc.

71. Figure 48.12-1 Na  Action potential Axon Plasma membrane Cytosol 1

72. Figure 48.12-2 KK KK Na  Action potential Axon Plasma membrane Cytosol Action potential 21

73. Figure 48.12-3 KK KK KK KK Na  Action potential Axon Plasma membrane Cytosol Action potential 213

75. Adaptation of Axon Structure The speed of an action potential increases with the axon’s diameter In vertebrates, axons are insulated by a myelin sheath, which causes an action potential’s speed to increase Myelin sheaths are made by glial cells— oligodendrocytes in the CNS and Schwann cells in the PNS © 2011 Pearson Education, Inc.

76. Axon Myelin sheath Schwann cell Nodes of Ranvier Node of Ranvier Layers of myelin Axon Schwann cell Nucleus of Schwann cell 0.1  m Figure 48.13

77. Figure 48.13a 0.1  m

78. Action potentials are formed only at nodes of Ranvier, gaps in the myelin sheath where voltage-gated Na + channels are found Action potentials in myelinated axons jump between the nodes of Ranvier in a process called saltatory conduction © 2011 Pearson Education, Inc.

79. Cell body Schwann cell Depolarized region (node of Ranvier) Myelin sheath Axon Figure 48.14

80. Key Points Neurons are built and organized for information transfer Ion pumps and ion channels establish the resting potential of a neuron Action potentials are the signals conducted by axons Neurons communicate with other cells at synapses Neurons communicate with other cells at synapses © 2011 Pearson Education, Inc.

81. Neurons communicate with other cells at synapses At electrical synapses, the electrical current flows from one neuron to another At chemical synapses, a chemical neurotransmitter carries information across the gap junction Most synapses are chemical synapses © 2011 Pearson Education, Inc.

82. The presynaptic neuron synthesizes and packages the neurotransmitter in synaptic vesicles located in the synaptic terminal The action potential causes the release of the neurotransmitter The neurotransmitter diffuses across the synaptic cleft and is received by the postsynaptic cell © 2011 Pearson Education, Inc.

83. Animation: Synapse Right-click slide / select “Play”

84. Presynaptic cell Postsynaptic cell Axon Presynaptic membrane Synaptic vesicle containing neurotransmitter Postsynaptic membrane Synaptic cleft Voltage-gated Ca 2  channel Ligand-gated ion channels Ca 2  Na  KK 2 1 3 4 Figure 48.15

85. Generation of Postsynaptic Potentials Direct synaptic transmission involves binding of neurotransmitters to ligand-gated ion channels in the postsynaptic cell Neurotransmitter binding causes ion channels to open, generating a postsynaptic potential © 2011 Pearson Education, Inc.

86. Postsynaptic potentials fall into two categories –Excitatory postsynaptic potentials (EPSPs) are depolarizations that bring the membrane potential toward threshold –Inhibitory postsynaptic potentials (IPSPs) are hyperpolarizations that move the membrane potential farther from threshold © 2011 Pearson Education, Inc.

87. After release, the neurotransmitter –May diffuse out of the synaptic cleft –May be taken up by surrounding cells –May be degraded by enzymes © 2011 Pearson Education, Inc.

88. Summation of Postsynaptic Potentials Most neurons have many synapses on their dendrites and cell body A single EPSP is usually too small to trigger an action potential in a postsynaptic neuron © 2011 Pearson Education, Inc.

89. Figure 48.16 Postsynaptic neuron Synaptic terminals of pre- synaptic neurons 5  m

90. Act 1 Scene 1: Neurons @ work

91. Figure 48.17 Terminal branch of presynaptic neuron Postsynaptic neuron Axon hillock E1E1 E2E2 E1E1 E2E2 E1E1 E2E2 E1E1 E2E2 I I I I 0  70 Membrane potential (mV) Threshold of axon of postsynaptic neuron Resting potential Action potential I E1E1 E1E1 E1E1 E1E1 E 1  E 2 E1  IE1  I Subthreshold, no summation (a) (b) Temporal summation (c) Spatial summation Spatial summation of EPSP and IPSP (d) E1E1

92. If two EPSPs are produced in rapid succession, an effect called temporal summation occurs © 2011 Pearson Education, Inc.

93. Terminal branch of presynaptic neuron Postsynaptic neuron Axon hillock E1E1 E2E2 E1E1 E2E2 I I 0  70 Membrane potential (mV) Threshold of axon of postsynaptic neuron Resting potential Action potential E1E1 E1E1 E1E1 E1E1 Subthreshold, no summation (a)(b) Temporal summation Figure 48.17a

94. In spatial summation, EPSPs produced nearly simultaneously by different synapses on the same postsynaptic neuron add together The combination of EPSPs through spatial and temporal summation can trigger an action potential © 2011 Pearson Education, Inc.

95. E1E1 E2E2 E1E1 E2E2 I I Action potential I E 1  E 2 E1  IE1  I (c) Spatial summation Spatial summation of EPSP and IPSP (d) E1E1 Figure 48.17b

96. Through summation, an IPSP can counter the effect of an EPSP The summed effect of EPSPs and IPSPs determines whether an axon hillock will reach threshold and generate an action potential © 2011 Pearson Education, Inc.

97. Modulated Signaling at Synapses In some synapses, a neurotransmitter binds to a receptor that is metabotropic In this case, movement of ions through a channel depends on one or more metabolic steps © 2011 Pearson Education, Inc.

98. Binding of a neurotransmitter to a metabotropic receptor activates a signal transduction pathway in the postsynaptic cell involving a second messenger Compared to ligand-gated channels, the effects of second-messenger systems have a slower onset but last longer © 2011 Pearson Education, Inc.

99. Neurotransmitters There are more than 100 neurotransmitters, belonging to five groups: –acetylcholine –biogenic amines –amino acids –neuropeptides –and gases A single neurotransmitter may have more than a dozen different receptors © 2011 Pearson Education, Inc. Botulinum toxin

100. Table 48.2

101. Acetylcholine Acetylcholine is a common neurotransmitter in vertebrates and invertebrates It is involved in muscle stimulation, memory formation, and learning Vertebrates have two major classes of acetylcholine receptor, one that is ligand gated and one that is metabotropic © 2011 Pearson Education, Inc.

102. Amino Acids Amino acid neurotransmitters are active in the CNS and PNS Known to function in the CNS are –Glutamate –Gamma-aminobutyric acid (GABA) –Glycine © 2011 Pearson Education, Inc.

103. Biogenic Amines Biogenic amines include –Epinephrine –Norepinephrine –Dopamine –Serotonin They are active in the CNS and PNS © 2011 Pearson Education, Inc.

104. Neuropeptides Several neuropeptides, relatively short chains of amino acids, also function as neurotransmitters Neuropeptides include substance P and endorphins, which both affect our perception of pain Opiates bind to the same receptors as endorphins and can be used as painkillers © 2011 Pearson Education, Inc.

105. Gases Gases such as nitric oxide and carbon monoxide are local regulators in the PNS © 2011 Pearson Education, Inc.

106. Key Points Neurons are built and organized for information transfer Neurons are built and organized for information transfer Ion pumps and ion channels establish the resting potential of a neuron Ion pumps and ion channels establish the resting potential of a neuron Action potentials are the signals conducted by axons Action potentials are the signals conducted by axons Neurons communicate with other cells at synapses Neurons communicate with other cells at synapses © 2011 Pearson Education, Inc.

107. Cell Signaling Supplement Packet (p.25)