1. 32409 Small intestine Large intestine Small intestine Intestine, liver, gall bladder, and pancreas

2. General Structure of the Digestive Tract Epithelium with goblet cells and absorptive cells Lamina propria Muscularis mucosa Submucosa Muscularis externa (tunica muscularis) Serosa 32409 central lacteal rat

3. Slide #37 (Ed 904-64b). Slide #37 (Ed 904-64b). Small intestine, donkey. Mesothelium of serosa lamina propria the myenteric (“Auerbach’s) plexus located between the inner circular and outer longitudinal smooth muscle layers of the tunica muscularis neuronal cell bodies of the submucosal (“Meissner’s) plexus tunica muscularis muscularis mucosa central lacteal submucosal (Brunner’s) glands intestinal crypts (glands of Lieberkuhn) muscularis mucosa

4. Slide #37 (Ed 904-64b). Slide #37 (Ed 904-64b). Small intestine, donkey. brush” or “striated” border = High density of non-branching microvilli of uniform length. Intestinal absorptive cells Simple columnar epithelium Paneth cells Paneth cell Goblet cell Microfilaments are the cytoskeleton component in microvilli

5. Slide #37 Slide #37 (Ed 904-64b). Small intestine, donkey Mitotic figures Enteroendocrine Cells (EC cells) Absorptive cells Paneth cells

6. Slide #37 (Ed 904-64b). Slide #37 (Ed 904-64b). Small intestine, donkey.

7. Enteroendocrine cells in fundic stomach, rabbit (toluidine blue) 244 Enteroendocrine cells Chief cells Parietal cell To see the distribution of EC cells among glands

8. Duodenum, monkey 146 Submucosal Brunner's glands. Goblet and absorptive cells, Enteroendocrine cell Crypts of Lieberkühn Lamina propria. Muscularis mucosa Submucosa

9. Duodenum 152 Brunner’s glands Intestinal villus Absorptive cells Enteroendocrine cell Goblet cells Paneth cell

10. Slide #37 Slide #37 (Ed 904-64b). Small intestine, donkey. Enteroendocrine cells

11. DEMO SLIDE BOX 57 DEMO SLIDE BOX 57 -­‐ Small intestine (ileum), dog. Intestinal crypts (glands Or Crypts of Lieberkuhn lamina propria of the villi central lacteals Peyer’s patches Goblet cell Smooth Muscle in Intestinal villus

12. Enteroendocrine cell DEMO SLIDE BOX 57 DEMO SLIDE BOX 57 -­‐ Small intestine (ileum), dog. Intestinal crypts (glands Or Crypts of Lieberkuhn

13. DEMO SLIDE BOX 225 (C-­‐H-­‐73DEMO SLIDE BOX 225 (C-­‐H-­‐73). Small intestine (jejunum), dog. epithelial Modifications = Brush border and goblet cells Strips of Muscularis mucosa central lacteal lamina subglandularis muscularis mucosa submucosa Absorptive cells

14. DEMOSLIDE BOX 225 (C-­‐H-­‐73DEMOSLIDE BOX 225 (C-­‐H-­‐73). Small intestine (jejunum), dog. lamina subglandularis stratum granulosum stratum compactum muscularis mucosa lamina subglandularis submucosa Enteroendocrine cells Paneth cells Absorptive cells

15. DEMOSLIDE BOX 225 (C-­‐H-­‐73). DEMOSLIDE BOX 225 (C-­‐H-­‐73). Small intestine (jejunum), dog. lamina subglandularis Crypts of Lieberkuhn Submucosal (“Meissner’s”) myenteric (“Auerbach’s”) plexuses tunica muscularis submucosa muscularis mucosa serosa. Mesothelium of serosa Smooth muscle cells

16. Slide #192 (Pf 5-­‐84d). Slide #192 (Pf 5-­‐84d). Small intestine (jejunum), pig.. Absorptive cells submucosa muscularis mucosa lamina propria tunica muscularis

17. Slide #192 (Pf 5-­‐84d). Slide #192 (Pf 5-­‐84d). Small intestine (jejunum), pig. Enteroendocrine cellsPaneth cells lamina propria Smooth muscle cells of the muscularis mucosa central lacteal Intestinal absorptive cells Simple columnar epithelium Goblet cell Brush border of absorptive cells

18. Slide #89 (83 DF1) Slide #89 (83 DF1) – Small intestine, puppy (dog). Epithelium Lamina propria Muscularis mucosa Submucosa tunica muscularis Serosa

19. Slide #89 (83 DF1) Slide #89 (83 DF1) – Small intestine, puppy (dog). central lacteal Lymph nodules Small intestinal villi Intestinal crypts (glands Or Crypts of Lieberkuhn

20. Slide #89 (83 DF1) Slide #89 (83 DF1) – Small intestine, puppy (dog). Dividing cells Epithelium Lamina propria Muscularis mucosa (developing) Submucosa with lymphoid cell infiltration tunica muscularis Serosa myenteric (“Auerbach’s”) plexuses Serosa mesothelium

21. Compare luminal surfaces of the small and large intestines NO Villi Villi small intestineslarge intestines

22. DEMO SLIDE BOX 167 (C003-­‐H-­‐29) DEMO SLIDE BOX 167 (C003-­‐H-­‐29) -­‐ Large intestine (cecum), dog. Epithelium Lamina propria Muscularis mucosa Submucosa tunica muscularis Serosa Lymph nodules Intestinal crypts (glands Or Crypts of Lieberkuhn Peyer’s patches villi are absent mesothelium Smooth muscle

23. DEMO SLIDE BOX 167 (C003-­‐H-­‐29)

24. DEMO SLIDE BOX 167 (C003-­‐H-­‐29) DEMO SLIDE BOX 167 (C003-­‐H-­‐29) -­‐ Large intestine (cecum), dog. Epithelium Lamina propria Intestinal crypts (glands Or Crypts of Lieberkuhn villi are absent Muscularis mucosa Enteroendocrine cells absorptive cells and goblet cells

25. DEMO SLIDE BOX 61DEMO SLIDE BOX 61. Large intestine (colon), cat. Epithelium Lamina propria Muscularis mucosa (developing) Submucosa with lymphoid cell infiltration tunica muscularis Serosa

26. DEMO SLIDE BOX 61DEMO SLIDE BOX 61. Large intestine (colon), cat. Epithelium Lamina propria Muscularis mucosa Submucosa absorptive cells goblet cells Intestinal crypts (glands Or Crypts of Lieberkuhn

27. DEMO SLIDE BOX 171 (E3-­‐H-­‐38). DEMO SLIDE BOX 171 (E3-­‐H-­‐38). Large intestine (colon), horse. Lymph nodules the taenia coli; a gross thickening of the longitudinal layer of tunica muscularis in the horse. taenia coli Intestinal crypts (glands Or Crypts of Lieberkuhn

29. DEMO SLIDE BOX 168 (C003-­‐H-­‐38) DEMO SLIDE BOX 168 (C003-­‐H-­‐38) -­‐ Large intestine (colon), dog. Epithelium with goblet cells and absorptive cells Lamina propria Muscularis mucosa Submucosa Muscularis externa (tunica muscularis) Serosa Intestinal crypts (glands Or Crypts of Lieberkuhn

30. DEMO SLIDE BOX 168 (C003-­‐H-­‐38) DEMO SLIDE BOX 168 (C003-­‐H-­‐38) -­‐ Large intestine (colon), dog. Intestinal crypts (glands Or Crypts of Lieberkuhn Enteroendocrine cells

31. Slide #43 Slide #43 (K9-­‐1). Anal region, dog. the recto-­‐anal junction and regional skin. regional skin rectum skin nonkeratinized stratified squamous epithelium goblet cells located in the crypts circumanal glands (perianal glands) which can become neoplastic

32. Slide #43 (K9-­‐1). Slide #43 (K9-­‐1). Anal region, dog. keratinized stratified squamous epithelium

33. Slide #43 (K9-­‐1). Slide #43 (K9-­‐1). Anal region, dog the circumanal glands (perianal glands) in this region Walled off with CCT parasite CCT external anal sphincter = bundles of skeletal muscle

34. DEMO SLIDE BOX 62-DEMO SLIDE BOX 62-­‐ Rectum and anal canal, dog. Again the simple columnar epithelium is missing. Note the approximate recto-­‐anal junction. At this junction, there is an abrupt change to nonkeratinized stratified squamous epithelium. Near the junction of nonkeratinized and keratinized stratified squamous epithelium, observe the large invagination of the anal sac. The inner circular layer of the tunica muscularis is somewhat thickened to form the internal anal sphincter. The skeletal muscle fibers are part of the external anal sphincter. The anal canal is continuous with the skin of the perineal region (note the change in epithelium to keratinized stratified squamous); see the circumanal (perianal) glands the circumanal (perianal) glands large invagination of the anal sac. rectum simple columnar epithelium skin

35. DEMO SLIDE BOX 62-DEMO SLIDE BOX 62-­‐ Rectum and anal canal, dog. the circumanal (perianal) glands large invagination of the anal sac. rectum skin skeletal muscle fibers are part of the external anal sphincter tunica muscularis (smooth muscle) is somewhat thickened to form the internal anal sphincter. rectum skin nonkeratinized stratified squamous epithelium keratinized stratified squamous

36. Slide #77 (C007-­‐H-­‐107A). Slide #77 (C007-­‐H-­‐107A). Pancreas, dog. CENTROACINAR CELLS ARE THE BEGINNING CELLS OF THE INTERCALATED DUCTS THAT DRAIN THE SECRETORY ACINI OF THE PANCREAS. THEY SECRETE BICARBONATE serous acini INTERCALATED DUCTS pancreatic islets

37. Bile Canaliculi Bile duct Bile luminal surfaces Blood luminal surface 155

38. Slide #77 Slide #77 (C007-­‐H-­‐107A). Pancreas, dog. INTERCALATED DUCTS pancreatic islets Pancreas has Islets and centroacinar cells, but no striated ducts The salivary gland has striated ducts, but no Islets and centroacinar cells Demo 186 Salivary gland Striations in base of duct cells

39. Slide #193 Slide #193 (GT-­‐1-­‐102). Pancreas, goat. INTERCALATED DUCTS CENTROACINAR CELLS pancreatic islets

40. DEMO SLIDE BOX 180 DEMO SLIDE BOX 180– Small intestine (duodenum) and pancreas, dog. (157) CENTROACINAR CELLS pancreatic islet

41. Slide #93 (1017) Slide #93 (1017) -­‐ Pancreas and duodenum, cat.) CENTROACINAR CELLS Dispersed pancreatic islet cells Pancreas duodenum

43. Portal radicles containing: A bile duct Branch of portal vein, Branch of hepatic artery Lymphatic vessel (usually) Liver or portal canals Cords of hepatocytes 155

44. Liver

45. Bile Canaliculi Bile duct Bile luminal surfaces Blood luminal surface 155

46. hepatocytes DEMO SLIDE BOX 169 DEMO SLIDE BOX 169 (P001-­‐H-­‐84B) – Liver, pig. hepatic lobules Sinusoids discontinuous

47. DEMO SLIDE BOX 169 DEMO SLIDE BOX 169 (P001-­‐H-­‐84B) – Liver, pig. hepatic lobule Hepatic sinusoids flow between rows of hepatocytes toward the central vein. capsule venule which is a branch of the portal vein arteriole, which is a branch of the hepatic artery either simple cuboidal or simple columnar epithelium Of bile duct. interlobular connective tissue are larger veins, not accompanied by an artery and a duct, named sublobular veins portal triad.

48. Slide #45 Slide #45 (Pig 1-­‐87c). Liver, Pig. hepatic lobule venule bile duct artery Central vein portal triad.

49. DEMO SLIDE BOX 170 DEMO SLIDE BOX 170 (E3-­‐H-­‐84-­‐1). Liver, horse. Hepatic sinusoids flow between rows of hepatocytes toward the central vein. portal triad. Space of Disse

50. HEPATOCYTE SPACE OF DISSE BILE CANALICULI

51. Slide #48 Slide #48 (PF5-­‐76B). Liver & gall bladder, pig. portal triad. central vein Mesothelium of capsule capsule Sinusoids discontinuous Kupffer cells

52. Slide #48 Slide #48 (PF5-­‐76B). Liver & gall bladder, pig. Mesothelium of capsule Kupffer cells (i.e. the liver macrophages lining the sinusoids) are noticeable because they ingested black portal triad. Kupffer cells Kupffer cells

53. Slide #48 Slide #48 (PF5-­‐76B). Liver & gall bladder, pig. gallbladder Microvilli occur apically but are difficult to see No muscularis mucosae occurs so the lamina propria blends with the submucosa. Note the tunica muscularis is not well organized. The thick layer of CCT outside the tunica muscularis is called the “perimuscular connective tissue” layer.

54. Slide #48 Slide #48 (PF5-­‐76B). Liver & gall bladder, pig. gallbladder

55. Slide #167 Slide #167 (M-­‐1 87F). Liver, monkey Kupffer cells Central vein

56. Slide #111 Slide #111 (87NG)—Liver, goat

57. Slide #117 Slide #117 (SP-­‐1-­‐61) -­‐ Liver and gallbladder, sheep.

58. Slide #117 Slide #117 (SP-­‐1-­‐61) -­‐ Liver and gallbladder, sheep.

59. Slide # 94 Slide # 94 (Rbt-­‐87G)—Liver, rabbit.

60. DEMO SLIDE BOX 58 DEMO SLIDE BOX 58 -­‐ Liver and gallbladder, dog.