2. Extra-embryonic membrane and placentation 陳建榮 http://web.nchu.edu.tw/~chenjr/index.htm

3. 胚外膜 (extraembryonic membrane): 1. 絨毛膜 (chorion) 2. 羊膜 (amnion) 3. 卵黃囊 (yolk sac) 4. 尿囊 (allantois)

4. Placenta 胎盤 Fetomaternal organ Fetal portion Fetal portion: villus chorion of chorionic sac Maternal portion: the functional layer of endometrium Endomatrial stromal cell  Decidual cell 蛻膜細胞 (decidual reaction)  decidua basalis Decidua: decidua basalis 基蛻膜 decidua capsularis 囊蛻膜 decidua parietalis 壁蛻膜

11. Villi: -primary chorionic villi -secondary chorionic villi -tertiary chorionic villi or stem villi Cytotrophoblastic shell 細胞滋養層殼

12. 絨毛膜板 Cytotrophoblastic shell 細胞滋養層殼

13. 胎盤膜 (placental membrane) 10 weeks full term 胎盤膜 (placental membrane) - 合體滋養層 - 細胞滋養層 - 絨毛的結締組織 - 胎兒微血管內皮

15. Erythroblastosis fetalis 胎性母紅血球增多症

16. Functions of Placenta - 代謝 (metabolism) -synthesis glycogen, cholesterol, fatty acids … - 運送氣體和營養素 - 營養 (nutrition) - 呼吸 (respiratory) - 排泄 (excrection) - 激素製造 (hormone production)

17. Placental abnormalities -Placenta percreta 植入性胎盤 -Placenta accreta 胎盤黏連 -Placenta previa 前置胎盤 Placental abnormalities

18. Uterine growth during pregnancy

19. Fetal membrane: amnion, yolk sac 3 week 4 week 10 wks 20 wks Amniotic fluid Amnion 羊膜 30ml 350ml

20. Amniotic fluid : -10 週 — 30ml; 20 週 — 350ml; 37 週 — 800-1000ml -Sources ： -amniotic cells, secretion of respiratory tract, maternal fluid, urine -Circulation ： - 未皮質化之皮膚 - 消化道吞食或呼吸道吸入，吸收後進入血流，再經胎盤交換 -Function ： - 平衡或對稱生長 - 提供自由運動 - 傳染疾病的壁障 (barrier) - 防止黏連 - 吸收震動 - 維持恆溫 Amniotic cavity

21. Allantosis and yolk sac 3 wks 9 wks 3 monthAdult

22. Yolk sac 卵黃囊 : -Nutrition (2 nd ~3 rd week) -Vasculogenesis and angiogenesis -Foregut, midgut and hindgut -Primordial germ cell Allantois 尿囊 -Derived from yolk sac -Vasculogenesis  umbilical a. and v. -Uninary bladder -Urachus  median umbilical lig.

23. Umbilical cord : -Connecting stalk, amnion -30~90cm -1 umbilical v. and 2 umbilical a. -False knots and true knots

27. False knot

28. Parturition (labor) 分娩 : 1.Dilation stage 擴張期 2.Expulsion stage 排出期 3.Placental stage 胎盤期 4.Recovery stage 恢復期

29. Parturition: 1. Dilation stage: 7-12 hrs Oxytocin 陣痛

30. 子宮開始收縮 ( 真陣痛 ) a. 子宮頸口變薄 b. 擴張子宮頸口 → 10 公分

31. Parturition: 2. Expulsion stage: 20’-50’

33. Parturition: 3. Placental stage: 15’ 4. Recovery stage > 2hrs

34. 胎頭過大、臀產式、胎兒窘迫 胎盤早期剝離、前置胎盤、臍帶脫出

36. 胞衣、胎衣（紫河車）

37. Dizygotic twins: separate

38. Dizygotic twins: fused

39. Monozygotic twins

41. Dizygotic (DZ) twins Monozygotic (MZ) twins (65%) Zygote2 1(2 embryoblasts) Fetal 2 amnions 2 amnions membrane 2 chorions or fused 1 chorion 2 placentas or fused 1 placenta Sex various same sex Genotype different same Incidence racial difference the same in population Rate increase with mother’s age independent with mother’s age Multiple pregnancies

42. Fetal membrane of bird Yolk sac Allantois Amnion Chorion Extraembryonic membrane of animals

43. Domestic animals

45. Classification Based on Placental Shape and Contact Points -Diffuse placenta 擴散型胎盤 : Seen in horses and pigs. -Cotyledonary placenta 子葉型胎盤 : This type of placentation is observed in ruminants. -Zonary placenta 帶狀胎盤 : Seen in carnivores like dogs and cats, seals, bears, and elephants. -Discoid placenta 盤狀胎盤 : Seen in primates and rodents.

46. Placentation in Horses Diffuse placenta 擴散胎盤

47. Placentation in Horses Diffuse placenta 擴散胎盤

48. Cotyledonary placenta 子葉型胎盤 Placentation in Ruminants

50. Placentation in Dogs and Cats Zonary placenta 帶狀型胎盤

53. Placentation in Dogs and Cats

54. Discoid placenta 盤狀胎盤 Human Rodent

55. 胎盤膜 (placental membrane)

56. Type of Placenta Maternal Layers Retained Examples Endometrial Epithelium Connective Tissue Uterine Endothelium Epitheliochorial 上皮絨毛膜型 +++ HorsesHorses, swine, ruminantsswine ruminants Endotheliochorial 內皮絨毛膜型 --+Dogs, cats Hemochorial 血液絨毛膜 --- HumansHumans, rodents, rabbitrodents

57. Epitheliochorial 上皮絨毛膜型

58. Summary of Species Differences in Placental Architecture Type of PlacentaCommon Examples Diffuse, epitheliochorial 擴散型胎盤, 上皮絨毛膜型 Horses and pigs Cotyledonary, epitheliochorial 子葉型胎盤, 上皮絨毛膜型 Ruminants (cattle, sheep, goats, deer) Zonary, endotheliochorial 帶狀胎盤, 內皮絨毛膜型 Carnivores (dog, cat, ferret) Discoid, hemochorial 盤狀胎盤, 血液絨毛膜 Humans, apes, monkeys and rodents

60. ? Cotyledonary epitheliochorial placenta

61. zonary endotheliochorial placenta ?