1. Association between Weight Gain and Symptoms of Gastroesophageal Reflux in the General Population Enrique Rey, Cristina Moreno-Elola-Olaso, Fernando Rodriguez Artalejo,G. Richard Locke III Am J Gastroenterol 2006;101:229–233 R4 김용남 /Prof. 장영운

2. Background Gastroesophageal reflux symptoms (GERS) –very common in western countries – 30% to 60% –pregnancy, overweight  a risk factor for GERS The association of overweight with GERS –might be a risk factor for GERS –Few data on this issue. weight during adult life or weight change over a decade –a relationship between weight gain and GERS. –short-term weight gain (occurring in months) as a risk factor for GERS.

3. Aim the relationship between weight change over 1 yr and the risk of GERS, independent of body mass index (BMI)

4. Methods 2500 people, both sexes aged 40–79 yr a random sample of the Spanish population -- the 2001 National Population Census. Telephone calls & interview Gastroesophageal Reflux Questionnaire (GERQ) –Onset, frequency, severity Weight, height, 1-year weight change –no weight gain, weight gain ≤5 kg, and weight gain >5 kg heartburn – burning feeling through the chest –Acid regurgitation with bitter, sour taste

5. Symptom –Frequency : at least weekly –Occasional : more seldom –Severe : intense to change lifestyle –Significant : at least weekly, severe to change lifestyle Duration –new : less than 1 yr duration –old : 1 yr or more duration

6. Results

12. Conclusion In summary, our study shows that short-term increase (more than 5kg/1year) in weight is associated with the development of new GERS and that this effect is independent of the BMI.