1. Follow-up of Brain Aneurysms treated with GDC coils after 6 years Finitsis S, Bracard S, Anxionnat R, Picard Luc Service de Neuroradiologie Diagnostique et Therapeutique Nancy, France

2.  Since 1992, prospective, single center, consecutive registry  The study included all patients treated up to 31/12/1998  Goal: patient population with a long-term follow-up of at least 6 years.

3. Methods  From 1992 until the end of 1998: 505 patients  89 patients fulfilled the criteria  Mean time of follow-up: 10,2 years sd. 2,1 years  Embolization with GDCs.  No use of balloon remodelling or stent

4. Patients  Mean age at the time of treatment: 44,7y (19 to 74 years)  67,4% females (60/89)  70% Single aneurysm (63/89)  30% Multiple aneurysms (2 to 4)  Total of 125 aneurysms  106 embolized with GDCs  12 followed  7 operated

5. Acom34%36/106 MCA21,7%23/106 Pcom18,8%20/106 Carotido-ophthalmic9%9/106 ICA bifurcation1,9%2/106 Pericallosal0,9%1/106 Choroidal0,9%1/106 Basilar tip5,7%6/106 Pica2,8%3/106 Vertebral2,8%3/106 SCA0,9%1/106 P20,9%1/106 Aneurysm Location

6. Subarachnoid Hemorrage 67,9%72/106 Fortuitous 27,4%29/106 Neurological Symptoms 4,7%5/106 Symptoms

7. Raymond Class Percentage Complete obliteration (I) 43,4%46/106 Neck remnant (II) 49,1%52/106 Partial filling (III) 7,5%8/106 Initial treatment results

8. Recurrences n Minor 5 Major 7 Further obliteration 5 5-years follow-up  During the 5 initial follow-up years:  16 patients had a 2 nd treatment  3 patients had a 3 rd treatment  1 patient was operated

9. 6-years and longer (mean 10,1 y)  8 major recurrences occurred  7,5% of aneurysms (8/106)  Location  3 Acom  2 MCA  1 Basilar tip  2 Vertebral artery  Management  1 follow-up  6 embolization  1 surgery

10. Correlations  Partial obliteration at 5 years (p<0,001)  2 or more retreatment sessions during the initial 5 years (p<0.001)  Vertebral artery location (p=0,015)  No recurrence occurred when the obliteration was complete at 5 year follow-up.  No correlation with initial symptoms (p=0,5), sex (p=0,8), age (p=0,4), multiplicity of aneurysms (p=0,8)

11. 1996 1997 2000 2003 2009

12. 1996 1998 2000 2002 2008

13. 1998 1999 2001 2004 2008

14. 1998 2000 2002 2005 2008 2009

15. 1994 1995 1998 20002001 2004

16. Conclusions  Reccurences after 6 years occurred in 7,5% (8/106) of aneurysms (mean follow-up of 10,1 years)  Correlated with:  a partial result at 5 years  2 or more retreatment sessions during the initial 5 years  vertebral artery location  No recurrence occurred when the obliteration was complete at 5 year follow-up.