1. detect and identify Bioanalytik 1 LB 930 BUTLER Plate Handling Robot

2. Bioanalytik 2 BUTLER LB 930 A Revolution in Automated Microplate Handling

3. Bioanalytik 3 High-speed plate handling Plate transfer in 6 seconds Pick plate Move up Rotate 180° Move down Release plate 0,4 ’’ 1,5 ’’ 2,8 ’’ 1,0 ’’ 0,4 ’’

4. Bioanalytik 4 Four degrees of freedom Move arm Move on track Up / Down Open / Close Gripper Rotate

5. Bioanalytik 5 Automated plate detection Detection of gripper motor force Teachable plate tolerance Payload 0.5 kg Portrait or landscape format No plate lost during / after power failure

6. Bioanalytik 6 Flexible work space design 97,3mm 332,3mm 263.8 mm 303.8 mm 420 mm 145 mm Z movement: 310 mm

7. Bioanalytik 7 SWAP Software - Outline User-friendly Windows 2000 based Method simulator Seamless integration of Berthold plate readers Mutual slave/master set-up Easy to integrate Direct control with firmware commands and CRLF protocol

8. Bioanalytik 8 Software - Programming 1. Deck Layout Editor 3. Run Editor 2. Method Editor

9. Bioanalytik 9 Deck layout editor Graphical user interface Free labware positioning

10. Bioanalytik 10 Method editor Drag & Drop Easy to program Method tree Syntax-free !

11. Bioanalytik 11 Run editor Start / Stop Pause Single step Trace file

12. Bioanalytik 12 Accessories Teaching Box Stack Holder Stacker Barcode Reader

13. Bioanalytik 13 Teaching Box Easy operation Fast position, teaching Emergency STOP button Two teaching speeds available Movable “Move” button “OK” button Emergency “STOP” button Move Axis Selection

14. Bioanalytik 14 Barcode Reader Horizontal and vertical BC reader Different barcode-formats Programmable Communication via RS 232 High resolution & security (double check possibility) Distance to barcode 5.. 50 cm

15. Bioanalytik 15 Stackers Stacker for up to 20 MTP or 6 DWP Portrait and Landscape Lid handling possible

16. Bioanalytik 16 Stacker System can be used with Mithras, Centro and Twinkle two models: Stacker 20 for 20 microplates BUTLER, universal base plate, 2 stackers Stacker 100 for 100 microplates BUTLER, extended universal base plate, 6 stackers

17. Bioanalytik 17 Stacker System 2 robot software and Mikrowin 2000 communicate via mutual status messaging preset programs Mikrowin 2000 Advanced I or II necessary each plate gets ist own data file

18. Bioanalytik 18 Integration Plate washer e.g. EMBLA 384 Incubator e.g. Cytomat 6000 Plate sealer e.g. ALPS 300 Vacuum pump e.g. ME 4C Vario Hotel e.g. Cytomat Microplate Hotel HS

19. Bioanalytik 19 Fields of Application General Plate replication Plate reformatting Drug Discovery Target discovery Compound discovery Secondary screening Primary screening Hit picking Diagnostics Forensic Science Genomics Science DNA isolation DNA normalisation PCR set-up PCR clean-up Combi-Chem Pharmacology

20. Bioanalytik 20 Summary High-speed plate handling (>100 plates / hour) Four degrees of freedom No plate lost during/after power failure Seamless integration of Berthold plate readers Low noise technology for agreeable laboratory working Automated plate detection Easy to teach with teaching box Integration of additional instruments possible Small footprint