1. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Analytic framework and key questions. ARDS = acute respiratory distress syndrome; HELLP = hemolysis, elevated liver enzymes, and low platelets. * Abbreviated list of health outcomes. See Appendix Table 2 for a full list. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Summary of evidence search and selection. The diagram excludes 51 RefMan (Thomson Reuters, Philadelphia, Pennsylvania) citations that were pulled for background or informational purposes only and were not systematically reviewed. KQ = key question. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Pooled analysis of preterm birth from trials of women at risk for preeclampsia, sorted by sample size. CLASP = Collaborative Low-dose Aspirin Study in Pregnancy; MFMU = Maternal-Fetal Medicine Units; NR = not reported; PE = preeclampsia; RR = relative risk. * From random-effects analysis. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Pooled analysis of intrauterine growth restriction from trials of women at risk for preeclampsia, sorted by sample size. CLASP = Collaborative Low-dose Aspirin Study in Pregnancy; MFMU = Maternal-Fetal Medicine Units; NR = not reported; PE = preeclampsia; RR = relative risk. * From random-effects analysis. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Pooled analysis of preeclampsia from trials of women at risk for preeclampsia, sorted by sample size. CLASP = Collaborative Low-dose Aspirin Study in Pregnancy; MFMU = Maternal-Fetal Medicine Units; PE = preeclampsia; RR = relative risk. * From random-effects analysis. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Pooled analysis of perinatal mortality from all trials, sorted by sample size. CLASP = Collaborative Low-dose Aspirin Study in Pregnancy; MFMU = Maternal-Fetal Medicine Units; NR = not reported; PE = preeclampsia; RR = relative risk. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

7. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Pooled analysis of placental abruption from all trials, sorted by sample size. CLASP = Collaborative Low-dose Aspirin Study in Pregnancy; MFMU = Maternal-Fetal Medicine Units; PE = preeclampsia; RR = relative risk. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

8. Date of download: 6/21/2016 From: Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med. 2014;160(10):695-703. doi:10.7326/M13-2844 Pooled analysis of intracranial fetal bleeding from all trials, sorted by sample size. CLASP = Collaborative Low-dose Aspirin Study in Pregnancy; MFMU = Maternal-Fetal Medicine Units; NR = not reported; PE = preeclampsia; RR = relative risk. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians