1. Pre-natal Exposure to Environmental Allergens and Food Allergy Immunopathogenesis Mary Prunicki MD PhD, Erik Klingbeil BS, Grace Leu BS Stefania Arasi MD, Kari Nadeau MD PhD Stanford University, School of Medicine Dept. Pediatrics, Allergy, Asthma & Immunology Sean N. Parker Center for Allergy Research Lucile Packard Children’s Hospital Stanford Hospital & Clinics

2. Background

3. DESIGN: Community-based case-control study. CASE SELECTION: Selected participants and the mothers of participants enrolled in oral immunotherapy (OIT) studies at the Sean N. Parker Center for Allergy Research at the Stanford University, School of Medicine. Allergic status based upon: (1) Skin Prick Test (2) Specific IgE Test (3) Oral Food Challenge CONTROL SELECTION: Selected non-allergic members of the surrounding community that live in the same geographic area as selected cases. TIMELINE: January 2014 to January 2015. Methods

6. Pre-Natal Dog Exposure Associated With Protection Against Food Allergy

7. Pre-Natal Chemical Exposure No Association With Food Allergy

8. Pre-Natal Peanut Consumption Associated With Food Allergy

9. Discussion Pet Dandervs. Dog-Specific Behaviors

10. Discussion Epigenetics

11. Discussion Polarization

12. Discussion