1. QUICK DESIGN GUIDE (--THIS SECTION DOES NOT PRINT--) This PowerPoint 2007 template produces a 48”x96” professional poster. It will save you valuable time placing titles, subtitles, text, and graphics. Use it to create your presentation. Then send it to PosterPresentations.com for premium quality, same day affordable printing. We provide a series of online tutorials that will guide you through the poster design process and answer your poster production questions. View our online tutorials at: http://bit.ly/Poster_creation_help (copy and paste the link into your web browser). For assistance and to order your printed poster call PosterPresentations.com at 1.866.649.3004 Object Placeholders Use the placeholders provided below to add new elements to your poster: Drag a placeholder onto the poster area, size it, and click it to edit. Section Header placeholder Use section headers to separate topics or concepts within your presentation. Text placeholder Move this preformatted text placeholder to the poster to add a new body of text. Picture placeholder Move this graphic placeholder onto your poster, size it first, and then click it to add a picture to the poster. RESEARCH POSTER PRESENTATION DESIGN © 2011 www.PosterPresentations.com QUICK TIPS (--THIS SECTION DOES NOT PRINT--) This PowerPoint template requires basic PowerPoint (version 2007 or newer) skills. Below is a list of commonly asked questions specific to this template. If you are using an older version of PowerPoint some template features may not work properly. Using the template Verifying the quality of your graphics Go to the VIEW menu and click on ZOOM to set your preferred magnification. This template is at 50% the size of the final poster. All text and graphics will be printed at 200% their size. To see what your poster will look like when printed, set the zoom to 200% and evaluate the quality of all your graphics before you submit your poster for printing. Using the placeholders To add text to this template click inside a placeholder and type in or paste your text. To move a placeholder, click on it once (to select it), place your cursor on its frame and your cursor will change to this symbol: Then, click once and drag it to its new location where you can resize it as needed. Additional placeholders can be found on the left side of this template. Modifying the layout This template has four different column layouts. Right-click your Mouse on the background and click on “Layout” to see the layout options. The columns in the provided layouts are fixed and cannot be moved but advanced users can modify any layout by going to VIEW and then SLIDE MASTER. Importing text and graphics from external sources TEXT: Paste or type your text into a pre-existing placeholder or drag in a new placeholder from the left side of the template. Move it anywhere as needed. PHOTOS: Drag in a picture placeholder, size it first, click in it and insert a photo from the menu. TABLES: You can copy and paste a table from an external document onto this poster template. To make the text fit better in the cells of an imported table, right-click on the table, click FORMAT SHAPE then click on TEXT BOX and change the INTERNAL MARGIN values to 0.25 Modifying the color scheme To change the color scheme of this template go to the “Design” menu and click on “Colors”. You can choose from the provide color combinations or you can create your own. © 2011 PosterPresentations.com 2117 Fourth Street, Unit C Berkeley CA 94710 posterpresenter@gmail.com Student discounts are available on our Facebook page. Go to PosterPresentations.com and click on the FB icon Impact of Timing of Recurrence Following Catheter Ablation of Scar-Related Ventricular Tachycardia on Subsequent Mortality INTRODUCTION Todd B. Mendelson, MD, Joe Fahed, MD, Daniele Muser, MD, Jeffrey P. Gordon, MD, Matthew Hyman, MD, PhD, Erica S. Zado, PA, Sanjay Dixit, MD, FHRS, Mathew D. Hutchinson, MD, FHRS, Robert Schaller, DO, David S. Frankel, MD, FHRS, Michael P. Riley, MD, PhD, David Lin, MD, Fermin C. Garcia, MD, Gregory Supple, MD, David J. Callans, MD, Pasquale Santangeli, MD and Francis E. Marchlinski, MD, FHRS. CONCLUSIONS Disclosures: None pertinent to this study  Timing of VT recurrence following catheter ablation of scar-related VT has a strong impact on subsequent risk of mortality.  Patients experiencing VT recurrence within 1-6 months from the procedure are at particularly high risk.  These data support the importance of intense post-ablation monitoring for at least 6 months after the procedure to identify patients with early VT recurrence who may benefit from additional therapeutic interventions to improve survival RESULTS METHODS Electrophysiology Section, Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, PA  Radiofrequency catheter ablation (RFA) has an established therapeutic role in managing recurrent scar-related ventricular tachycardia (VT).  The risk of recurrent arrhythmia is still substantial and the appropriate intensity of post-ablation monitoring unknown.  The clinical implication of timing of post- ablation VT recurrence has not been adequately investigated. Figure 2: Survival Stratified By Time of Recurrence. Characteristic Mean or Number Range or Percent Age59.8 yrs18-87 yrs Male10487 % DM2218% CAD6756% COPD2017% OSA108% PAD87% BUN mmol/L204-90 Cr > 1.5 mg/dL2218% Sys BP mm Hg125.288-160 VT Storm5143% NYHA III or IV1613% LV EF39 %10-75 % LVEDD57.7 mm33-90 mm RV Dysfunction1815%  We studied 120 consecutive patients with scar-related VT with at least 6 months of post-ablation arrhythmia monitoring. Electrophysiologic study and RFCA  Conscious sedation was used when possible. General anesthesia with an inhaled agent (typically sevoflurane) was used when necessary at the discretion of the operator or anesthesiologist involved in the procedure.  Hemodynamically tolerated VT(s) targeted with entrainment mapping. Hemodynamically unstable VT(s) targeted with substrate modification performed with linear and/or cluster lesions targeting sites identified by pace mapping and late potentials. Figure 1: Distribution of Recurrence 8 (15%) 17 (32%) 28 (53%)  Over a mean follow-up of 23 ± 5 months, 53 (44%) patients had recurrent VT. Out of these 53 patients, 8 (15%) had very-early recurrence, 17 (32%) early recurrence, and 28 (53%) late recurrence (Figure 1). Study Endpoint To evaluate the impact of timing of VT recurrence on subsequent mortality.  Timing of VT recurrence was classified as very-early ( 6 months). Clinical Follow-Up  Follow-up at 4 to 8 weeks after ablation, and then at 3- to 6-month intervals.  SSDI database queried to verify the time to death.  Demographic/clinical data were obtained by retrospective chart review.  At 2 years, mortality rates were significantly higher in patients with very-early VT recurrence (43%) compared to those with early (14%), late (7%) and no (3%) recurrences (P<0.001 for comparison) (Figure 2).