1. Immunogenetics chapter 21 pp. pp. 620-627

2. Lines of Defense Physical and Chemical Physical and Chemical Immune system Immune system 3 rd line 1 st and 2 nd lines

3. First line of defense First line of defense

4. Second line of defense Second line of defense

5. 3 rd line of defense “The Immune System”

6. Summary Lines of Defense

7. Immune System B cells T cells

9. Lymph nodes are contain high concentrations lymphocytes

10. Let’s now look at the specific lymphocytes that reside in these nodes.

11. B Cell Humoral Immunity Humoral Immunity –Antibody Mediated

13. The Antibody

14. Antibody Diversity How do we acquire so many different types of antibodies? How do we acquire so many different types of antibodies? –Somatic recombination –Junctional diversity –hypermutations

15. Somatic Recombination http://www.bio.davidson.edu/courses/Im munology/Flash/somaticrecomb.html http://www.bio.davidson.edu/courses/Im munology/Flash/somaticrecomb.html http://www.bio.davidson.edu/courses/Im munology/Flash/somaticrecomb.html http://www.bio.davidson.edu/courses/Im munology/Flash/somaticrecomb.html

16. Antibody genes are composed of segments V J C

18. Antibody Production and Vaccinations

19. Antibody Production

20. Vaccinations Passive vaccines Passive vaccines Active vaccines Active vaccines

21. T Cells VJC (D)

22. T cells classification Helper T Cell Helper T Cell Cytotoxic T Cells Cytotoxic T Cells Memory T Cells Memory T Cells CD4+ CD4+ CD8+ CD8+

24. Cytotoxic T cell= CD8+

25. The major histocompatibility complex is a large group of genes on chromosome 6 is a large group of genes on chromosome 6

26. Tissue Transplantation MHC proteins differ between individuals MHC proteins differ between individuals

27. 2 types of MHC MHC I MHC I MHC II MHC II CD8+ cells recognizes endogenous antigens CD8+ cells recognizes endogenous antigens CD4+ cells recognizes exogenous antigens CD4+ cells recognizes exogenous antigens

28. Cytotoxic T Cell and MHC I Antigen presentation CD8+ cell

29. Cytotoxic T cell= CD8+

30. 2 types of MHC MHC I MHC I MHC II MHC II CD8+ cells recognizes endogenous antigens CD8+ cells recognizes endogenous antigens CD4+ cells recognizes exogenous antigens CD4+ cells recognizes exogenous antigens

31. Helper T Cell and MHC II Antigen presentation

32. B lymphocytes source of antibodies Overview of T lymphocytes

33. Cancer cell being attacked by cytotoxic T cells After release of perforin

34. Onto our discussion of cancer genetics

36. Allergic Response I.

37. Allergic Response II.