1. BRITTANY HAGEN BS RN OCN CCRC CLINICAL RESEARCH MANAGER OHC, INC. OHC Research

2. OHC – An Overview Founded in 1985, OHC is the Largest Private Oncology Practice in the Region Oncology Medical Home Specialists in Cancer and Blood Disorders  Medical Oncology, Radiation Oncology, Gynecologic Oncology, Neuro Oncology, Blood Cancers and Palliative Care  Performed More Bone Marrow Transplants than Any Other Provider in Region 17 Offices - Ohio, Kentucky and Indiana  7 Offices with Research Staff On Site Partnership with Sarah Cannon Research Institute  Largest Clinical Trial Menu in Region  More than 120 Available Clinical Trials  TWICE Received ASCO’s Clinical Trials Participation Award  Nationwide, Only TWO Practices Have Received This Designation More Than Once

3. OHC Research – An Overview Leadership Team:  Dave Waterhouse, Chair of Research  Lynnetta Hart, Director of Research  Brittany Hagen, Research Clinical Manager  Nicole Given, Research Non-Clinical Manager Staff:  12 Research Nurses  3 Research Assistants  3 Regulatory Specialists  6 Data Managers  1 Budgets & Contracts Specialist  1 Personalized Medicine Navigator  1 Research Blood Cancer Program Coordinator  1 Administrative Assistant

4. OHC Research What Types of Trials Do We Offer?  Pharmaceutical Intervention Studies  Observational Studies  Chart Review Studies  Correlational Studies How Do Our Doctors Know About the Trials?  Clinical Trial Review  Internal Communication  OHC Intranet How Do Patients Get Enrolled?  MD Presentation  RN Discussion

5. OHC Research – Job Functions Regulatory  Training, IRB Communications, Trial Management Data Management  Data Entry, Query Resolution, Audit Preparation Research Assistants  Lab Kit Assembly, Central Labs, Tissue Collection, Bone Marrow Collection, EKGs, Imaging Clinical Research Data Nurses  Query Resolution, SAE Reports and Follow-Ups, Audit Responses, Screening

6. OHC Research – Job Functions Research Nurse  ‘Study Coordinator’ and MORE  RN Requirement, Previous Experience in Oncology or Research Preferred, Certifications Encouraged  Nine pursuing BSN, MSN, MBA  Screening, Enrollment, Study Visits, Protocol Assessments, Submission of Clean Data, Coordination of Care  Documentation of Adverse Events, Concomitant Medications, Assessments, Training  Works Closely with Investigators  Develops Relationships with Other OHC Non-Research Staff Members

7. OHC Research – A Day in the Life Eight or Ten Hour Days  Office Dependent Office Maintenance  Temperatures, Drug Inventory, Filing Paperwork Emails, Emails, Emails  Monitors, Sponsors and Internal Patient Visits  Assess Patient, Dispense Drug, Training, Monitoring, Central Labs Documentation, Documentation, Documentation Screening  RNs Responsible for New Patients, MDs Responsible for Existing Patients Trainings  SIVs, Investigator Meetings, OHC SOPs

8. OHC Research - Speedbumps Non-Research OHC Staff  Buy-In  Building Relationships  Mutual Understanding of Job Functions Turnover  Constant  Sponsors, CROs  Combatting the Loss Enrollment  Ebbs and Flows  Pressure from MDs, OHC, SCRI, Sponsors

9. OHC Research – Future Strategic Planning Phase I Opportunities  First Phase I Trial Opened in March 2014  Fourteen Through Today Inpatient Bone Marrow Studies  Jewish Hospital BMT Unit  Acute Leukemics, Graft Versus Host Disease Radiation Oncology Studies

10. #WorldCancerDay