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The anti ‐ hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ ‐ dependent inhibition of the AKT pathway by Suzana Assad Kahn, Silvia.

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Presentation on theme: "The anti ‐ hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ ‐ dependent inhibition of the AKT pathway by Suzana Assad Kahn, Silvia."— Presentation transcript:

1 The anti ‐ hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ ‐ dependent inhibition of the AKT pathway by Suzana Assad Kahn, Silvia Lima Costa, Sharareh Gholamin, Ryan T Nitta, Luiz Gustavo Dubois, Marie Fève, Maria Zeniou, Paulo Lucas Cerqueira Coelho, Elias El ‐ Habr, Josette Cadusseau, Pascale Varlet, Siddhartha S Mitra, Bertrand Devaux, Marie ‐ Claude Kilhoffer, Samuel H Cheshier, Vivaldo Moura ‐ Neto, Jacques Haiech, Marie ‐ Pierre Junier, and Hervé Chneiweiss EMBO Mol Med. Volume ():e201505421 April 4, 2016 ©2016 by European Molecular Biology Organization

2 Prazosin inhibits GIC survival Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

3 Prazosin induces GIC apoptosis Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

4 Extreme limiting dilution assay of GBM44 Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

5 Prazosin inhibits glioblastoma growth in vivo Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

6 Prazosin inhibits glioblastoma growth in immunocompetent mice Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

7 Prazosin induces GIC apoptosis independently from α ‐ AR Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

8 Prazosin ‐ induced apoptosis is accompanied with reduced GIC proliferation Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

9 Prazosin induces GIC apoptosis in a PKCδ ‐ dependent manner Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

10 PKCδ expression and silencing in GIC and differentiated cells Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

11 Prazosin inhibits glioblastoma growth in vivo in a PKCδ ‐ dependent manner Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

12 PKCδ expression is associated with a poorer prognosis in human patients Suzana Assad Kahn et al. EMBO Mol Med. doi:10.15252/emmm.201505421 ©2016 by European Molecular Biology Organization

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