1. INTRA-VENOUS INDUCTION AGENTS Dr.M.Kannan MD DA Professor And HOD Department of Anaesthesiology Tirunelveli Medical College

3. General Anaesthesia Premedication Set up Intravenous line Set up Essential Monitors Induction Maintenance Recovery Post operative Care

4. Thiopental Sodium Yellowish Powder pH 10.8 Given IV Tissue necrosis Intra arterial-

5. Phamacological Effect -Thiopental Sedation in 30 seconds Recovers in 5-10min CVS -Myocardial depressant -Peripheral vasodilator RS-depression Placental transfer-Yes

6. Indication Induction of Anaesthesia Status Epilepsy To reduce cerebral oedema Truth extractor

7. Contraindication Relative Cardiac Failure Pericardial effusion Hypotension-shock Renal failure Absolute Porphyria-lower motor neuron paralysis Airway obstruction

8. Propofol-Pharmacology CNS-20-40 sec deep Sedation -Recovery 3-4min least hang over CVS Arterial pressure -Negative inotropic effect RS-Respiratory depressant

9. Propofol White Aqueous emulsion Soyabean oil & Purified egg phosphalipd Mild irritation to endothelium-pain

10. Propofol-Anaesthetic Indication Induction of Anaesthesia Sedation during regional Anaesthesia Total Intra venous Anaesthesia Sedation in ICU Preferred in Day care surgery

11. Ketamine Hydrochloride CNS –Sedation & 1-2 min lost for 10-15min Recovery-hallucination & nightmare Cerebral metabolism Cerebral blood flow No role in SOL

12. Ketamine Hydrochloride CVS -Hypertension -Tachycardia Oxygen Consumption

13. Ketamine-Respiratory system Mild depression Broncho dilator Asthmatic patient

14. Ketamine Indication Dose 2 mg/kg IV-10 mg/kg IM High risk patient-Shock Paediatric- Minor procedure Sedation-Dressing,Examination Developing countries

15. Ideal Intravenous Agent Rapid onset of action Rapid recovery Good analgesia No hangover effect No cardiac &Respiratory depression No local or allergic reaction No tachyphylaxis