1. Bringing Genomics Home Your DNA: A Blueprint for Better Health Genome British Columbia November 18, 2015 / West Vancouver, BC

2. Welcome and overview Dr. Brad Popovich (Genome BC) Overview of Genome BC and focus areas over the next 5 years Dr. Joe Connors (Professor, Department of Medicine, Division of Medical Oncology, University of British Columbia and BC Cancer Agency) Unlocking a genetically driven disease Dr. Stuart Turvey (Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia) Mystery patients: Using genomic tools to help diagnose and treat rare disease Dr. Mel Krajden (Senior Scientist, BCCDC Communicable Disease Prevention and Control Services) Hepatitis C: 25 years from discovery to cure Our objective today is to educate and inspire you about the growing role of genomics in healthcare in BC

3. A catalyst for the life sciences cluster on Canada's West Coast Our mission is to generate social and economic benefits through genomics Cumulative portfolio of over $710M in 254 genomics research projects and science and technology platforms Focusing on sectors of economic importance to BC and Canada: Human health Aquaculture & Fisheries Forestry Mining, Energy & Environment Agriculture Genome British Columbia

4. Why genomics? What is the impact on medicine?

5. Genomics: Provides an understanding of a disease from the inside out If you understand a disease at the DNA level, you understand the root cause of the disease Contrast this to looking at symptoms Genetic / genomic information is beneficial for disease Diagnosis Management Therapeutic management Family planning List of examples is rapidly growing

6. 100 Years 40 Years 30 Years First to ubiquitous

7. 19532000 DNA’s Journey 2014 Data Source: National Human Genome Research Institute http://www.genome.gov/sequencingcosts/

9. Next Generation Medicine

10. Genomic Medicine Continuum

11. Breadth of opportunities and need to focus 11 Health continuum Health & wellness Prevention & risk assessment Diagnosis Treatment & monitoring Disease / Condition Chronic diseases Infectious diseases Inherited conditions Health & wellness Benefits Improved health outcomes Improved healthcare system efficiency Economic growth Scientific discoveries Focus areas for clinical application Strategy for health research Near term feasibility Long term feasibility

12. Genome BC’s strategy for investment in health 12 Invest in genomic health research across diseases based on merit and potential impact Enable application of genomics at the level of populations Cancer, rare diseases, infectious diseases, pharmacogenomics* *Pharmacogenomics is the study of how genomic variation influences drug response (can be based on the genome of host / human, tumour, or infectious agent). Major cross-disease focus is on avoiding adverse events and optimizing dose across many diseases. Progression towards benefits Discovery and applied research Translational research Pilot then population level application Health-related need Potential genomic tool / technology Validated genomic tool / technology Health benefits for BC Investment phase Genome BC focus areas MIND THE GAP

13. 13 Prime opportunities for genomics in health in British Columbia (5 years) CancerRare Diseases / Rare Mutations Infectious DiseasesPharmacogenomics 1.Diseases with relatively simple genetics 2.Diseases where genomic information can influence healthcare 3.Technically and clinically feasible

14. Welcome and overview Dr. Brad Popovich (Genome BC) Overview of Genome BC and focus areas over the next 5 years Dr. Joe Connors (Professor, Department of Medicine, Division of Medical Oncology, University of British Columbia and BC Cancer Agency) Unlocking a genetically driven disease Dr. Stuart Turvey (Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia) Mystery patients: Using genomic tools to help diagnose and treat rare disease Dr. Mel Krajden (Senior Scientist, BCCDC Communicable Disease Prevention and Control Services) Hepatitis C: 25 years from discovery to cure Our objective today is to educate and inspire you about the growing role of genomics in healthcare in BC

15. Welcome and overview Dr. Brad Popovich (Genome BC) Overview of Genome BC and focus areas over the next 5 years Dr. Joe Connors (Professor, Department of Medicine, Division of Medical Oncology, University of British Columbia and BC Cancer Agency) Unlocking a genetically driven disease Dr. Stuart Turvey (Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia) Mystery patients: Using genomic tools to help diagnose and treat rare disease Dr. Mel Krajden (Senior Scientist, BCCDC Communicable Disease Prevention and Control Services) Hepatitis C: 25 years from discovery to cure Our objective today is to educate and inspire you about the growing role of genomics in healthcare in BC

16. Welcome and overview Dr. Brad Popovich (Genome BC) Overview of Genome BC and focus areas over the next 5 years Dr. Joe Connors (Professor, Department of Medicine, Division of Medical Oncology, University of British Columbia and BC Cancer Agency) Unlocking a genetically driven disease Dr. Stuart Turvey (Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia) Mystery patients: Using genomic tools to help diagnose and treat rare disease Dr. Mel Krajden (Senior Scientist, BCCDC Communicable Disease Prevention and Control Services) Hepatitis C: 25 years from discovery to cure Our objective today is to educate and inspire you about the growing role of genomics in healthcare in BC