1. Digital Tools for Clinical Development: Virtual Clinical Trials and Beyond 28 February 2012 Craig H. Lipset Pfizer American Society for Experimental NeuroTherapeutics | 15 th Annual Meeting

2. Disclosure Pfizer American Society for Experimental NeuroTherapeutics | 15th Annual Meeting Employee and Shareholder Content represents the opinion of the presenter and not necessarily the employer

3. Learning Objectives Describe lessons learned from prior experience deploying patient-centered technologies in clinical trials Determine impact of digital tools (including mobile, social media, and health information technology) on clinical trials going forward American Society for Experimental NeuroTherapeutics | 15th Annual Meeting

4. Digital Opportunities for Clinical Trials Mobile Recruitment Retention ePRO/Diaries Social Awareness Recruitment Data Sharing HIT Secondary Data Protocol Optimization Recruitment Site Selection EMR-EDC New Study Designs

5. Placing an ad on Facebook makes you “social”… … like placing an ad at Fenway Park makes you a baseball player.

6. Research 2.0: Patients Sharing Data to Find Cures Courtesy: 23andMe Research Revolution

7. the informed & engaged ePatient blinded & randomized clinical trial + = Partnering with ePatients Research Awareness Recruitment & Retention Patient Reported Outcomes Quantified Self Sharing Data Sharing Learnings

10. providers hospitals pharmacies labs research payers Patient as the Ideal Aggregator of Diverse Clinical Data Patients authorize and share electronic clinical data for research 91% Willing to Share Data for Research

11. Clinical Trials Participants Going Social How do we interpret CT signals? Eligibility Criteria Blinding Safety Reporting How do we interpret CT signals? Eligibility Criteria Blinding Safety Reporting

12. Approached by dozens of patients, may of whom became clinical trial participants Participated in a private Yahoo! Group for participants in her trial Compared specific experiences while in the study “People are out there [talking] and things have to be re-thought and re-designed”