1. DIVISION OF NEUROSCIENCE AND BEHAVIORAL RESEARCH (DNBR) NATIONAL ADVISORY COUNCIL ON DRUG ABUSE FEBRUARY 14, 2001 NIDA NATIONAL INSTITUTE ON DRUG ABUSE

2. Reorganization of DNBR WHY? NIDA NATIONAL INSTITUTE ON DRUG ABUSE

3. More efficiently identify the cause and consequence of substance abuse in order to improve treatment OVERALL: NIDA NATIONAL INSTITUTE ON DRUG ABUSE

4. Director: Dr. Glen Hanson Deputy Director for Program: Dr. David Shurtleff Deputy Director for Science and Technology Development: Dr. Karen Skinner Associate Director for Neuroscience Coordination: Dr. Roger Brown Special Assistant and Training Coordinator: Dr. Charles Sharp Deputy to Training Coordinator: Beth Babecki NIDA NATIONAL INSTITUTE ON DRUG ABUSE OFFICE OF DNBR DIRECTOR

5. Organized into 5 branches to reflect contemporary strategies and technologies Areas of interest assigned as they relate to basic science issues NIDA NATIONAL INSTITUTE ON DRUG ABUSE

6. Behavioral and Cognitive Science Research Branch Antecedent and consequent behavioral and cognitive factors to drug abuse, electro- physiological and systems processes and computational modeling NIDA NATIONAL INSTITUTE ON DRUG ABUSE Acting Chief: Dr. Minda Lynch Program Officers: Drs. Paul Schnur, Susan Volman & Cora Lee Wetherington

7. Chemistry and Physiological Systems Research Branch Analytical methods, basic chemistry, pharmacokinetics, perinatal effects, AIDS, neuroimmune function, and peripheral physiological systems NIDA NATIONAL INSTITUTE ON DRUG ABUSE Chief: Dr. Rao Rapaka Program Officers: Dr. Paul Hillary, Pushpa Thadani and Hari Singh

8. Pharmacology, Integrative and Cellular Neurobiology Research Branch Neuroendocrine modulation, cellular neuro- pharmacology, mechanisms of neurotrans- mission, neuropasticity, neurotoxicity and neuroprotection NIDA NATIONAL INSTITUTE ON DRUG ABUSE Acting Chief: Dr. Nancy Pilotte Program Officers: Drs. Jerry Frankenheim and Geraline Lin

9. Genetics and Molecular Neuro- biology Research Branch Genotypic and phenotypic factors, trans- criptional regulation, applied proteomics and basic cellular mechanisms NIDA NATIONAL INSTITUTE ON DRUG ABUSE Acting Chief: Dr. Jonathan Pollock Program Officers: Dr. Rebekah Rasooly, Two positions to be filled

10. Applied cognition, analgesic systems, neuro- imaging, technology development, clinical application of basic science, cooperative interest with other divisions, institutes and private sector Translational Research Branch NIDA NATIONAL INSTITUTE ON DRUG ABUSE Special interest: nicotine-related issues, pain, and frontal lobe mechanisms

11. Translational Research Branch NIDA NATIONAL INSTITUTE ON DRUG ABUSE Acting Chief: Dr. David Thomas Program Officers: Drs. Thomas Aigner and Herb Weingartner

12. MAJOR OBJECTIVES: NIDA NATIONAL INSTITUTE ON DRUG ABUSE

13. Factors contributing to addiction transition NIDA NATIONAL INSTITUTE ON DRUG ABUSE Neural development and its role in vulnerability to addiction Genetics of vulnerability Basic cognitive & behavioral processes related to drug abuse Use of emerging technologies (e.g. gene arrays)to study the addiction Proteomics to appreciate the role of proteins in the addiction process Translation

14. INITIATIVES NIDA NATIONAL INSTITUTE ON DRUG ABUSE RFA initiatives -Insertional Mutagenesis -Cutting Edge -GHB Initiative - Computational Supplement - Transition to Addiction Anticipated initiatives - Cognition and Frontal Lobes in Addiction - Protein Trafficking and Drugs of Abuse - Nicotine Workgroup (Translational Model)

15. NIDA NATIONAL INSTITUTE ON DRUG ABUSE QUESTIONS?