1. Uzhhorod National University

2. Uzhhorod National University, Ukraine EU Framework Programme for Research and Innovation "Horizon 2020" CBC program "Hungary- Slovakia-Romania-Ukraine" CBC program "Romania- Ukraine"

3. Uzhhorod National University Aim of the project: To verify newly created modern diagnostic system, which will enable to use human microbiota relationship with other biomarkers of human chronic diseases To develop and implement recommendations for personilazed approaches in preventive (early) diagnostic of patients with inflammation relevant chronic diseases

4. Uzhhorod National University Objectives: 1) To investigate the microbial status of patients (healthy and sick) of various chronic diseases relevant to inflammation; 2) Identification of targeted microorganisms, which clearly point to a specific disease; 3) Study of changes of immunological and “traditional” indications together with changing microbial balance in order to define real biomarkers; 4) Creation of new rapid diagnostic tools based on molecular data of host microbiota and their specific ratio for early diagnostic of various chronic diseases; 5) Recommendations to restore the microbial balance of patients

5. Uzhhorod National University Main expected results of the project: New and very specific diagnostic tools for early identification of various chronic diseases Effective prevention and treatment of inflammation relevant chronic diseases

6. Uzhhorod National University Main foreseen activities: Creating innovative methodologies, based on a several important indicators and microbiome ratio and which help to understand nature of same human disorders Testing (Astra-DIA) Cohort study Implementation in diagnostic medical practice

7. Uzhhorod National University Estimated Total Budget: 600-800 000,00 EUR Estimated duration: 36 months

8. Uzhhorod National University Neem Biotech Ltd Clinical-Microbiomics ApS EPMA Fraunhofer IIS, FIIS Сassovia Life Sciences

9. Uzhhorod National University Scientific Research & Educational Center of MM & IMM, UzhNU http://www.uzhnu.edu.ua/en/cat/deps-ndi_molecular Nadiya Boyko, Director nadiya.boyko@cassovialifesciences.eu Tel.:+380506275445 Olga Levchuk, PhD, contact person olgalevchuk27@gmail.com Tel.:+380994927511