1. Hematopoietic Cancers Common Disruptions 1

2. 2

3. 3

4. Burkitt’s Lymphoma 4

5. 5

6. 6 Endemic Lymphoma (comorbid with Malaria & EBV infection)

7. Epstein-Barr Virus (EBV)? Avian Myelocytomatosis Virus 7

8. 8

9. 9

10. 10

11. 11

12. N--C 12

13. bHLH E-box: CACGTG 13

14. 14

15. 15

16. 16

17. 17

18. 18

19. 19

20. cyclin D + CDK4 20

21. 21

22. 22

23. 23

24. 24

25. 25

26. ALL 26

27. Delta/Jagged Growth promoting gene transcription 27

28. Growth promoting gene transcription Extracellular 28

29. 29

30. CML 30

31. 31

32. 32

33. 33

34. 34

35. 35

36. 36

37. 37 ADPAmino acid (tyr) side chain

38. 38

39. 39

40. 40

41. 41 Imatinib

42. 42

43. 43

44. 44

45. 45

46. 46

47. 47

48. 48

49. 49

50. 50

51. 51

52. 52 Tumor regression Tumor relapse

53. 53

54. 54

55. CML 55 APL

56. 56 Clinical and Molecular Features: Severe bleeding tendency Promyelocytes in peripheral blood and bone marrow Chromosomal translocation between 17q21 and (often) 15q22 Fusion transcripts: PML-RAR 

57. 57

58. 58 differentiation genes

59. 59 ATRA

60. 60

61. Hodgkin’s Lymphoma 61

62. 62 Reed–Sternberg cells

63. 63

64. 64 Target Genes of NF-kB Cytokines/Chemokines and their Modulators Immunoreceptors Proteins Involved in Antigen Presentation Cell Adhesion Molecules Acute Phase Proteins Stress Response Genes Cell Surface Receptors Regulators of Apoptosis Growth Factors, Ligands and their Modulators Early Response Genes Transcription Factors Enzymes

65. AML 65

66. 66

67. c-Kit 67

68. 68

69. FLT3 69

70. 70