1. LEUKEMIA LEUKEMIA

2. Definition leukemia Leukemia – it is tumor, which erise from bloodforming cells and primary demages bone marrow Leukemia – it is tumor, which erise from bloodforming cells and primary demages bone marrow

3. Classification of leucosis Acute leucosis Acute leucosis myeloid myeloid lymphoid lymphoid Chronical leucosis Chronical leucosis myeloid myeloid lymphoid lymphoid

4. Acute myeloid leucosis Undifferentiated Undifferentiated Myeloblastic without maturate Myeloblastic without maturate Мyeloblastic с maturate Мyeloblastic с maturate Promyelocytic Promyelocytic Myelomonoblastic Myelomonoblastic Monoblastic Monoblastic Erythroblastic Erythroblastic Megakaryoblastic Megakaryoblastic

5. Histochemical criteries of acute leucosis differentiation 1. Peroxidase reaction 1. Peroxidase reaction 2. Acidic phosphatase reaction 2. Acidic phosphatase reaction 3. Unspecific esterase reaction 3. Unspecific esterase reaction 4. Lipid reaction 4. Lipid reaction 5. Compound carbohydrates reaction 5. Compound carbohydrates reaction

6. Reaction of myeloblastes and other cells of neutrophilic line of peroxidase

7. Reaction of monoblastes of α- naphtylacetateesterase

8. Reaction of myeloblastes and monoblastes of acidic phosphatase

9. Reaction with black sudan of lipids

10. Acidic sulfurated mucopolysaccharides reaction

11. Acute undifferentiated leucosis - blood

12. Acute undifferentiated leucosis – b. marrow

13. Acute undifferentiated leucosis– b. marrow. Аtypical cells

14. Acute myeloblastic – b. marrow. Initial stage. Granular myeloblast. Aur ’s stab

15. Acute myeloblastosis– b. marrow Тotal myeloblastic metaplasia

16. Acute myeloblastic leucosis – blood. Peroxidase reaction

17. Acute myeloblastic leucosis – b. marrow. Peroxidase reaction

18. Acute myeloblastosis – b. marrow Of the left – peroxidase reaction (2) Of the right – Aur ’s stab (2)

19. Acute myelomonoblastisis – b. marrow. Esterase reaction

20. Acute erythroblastosis – b. marrow Erythroblast double sprout sharp Myeloblast with Aur ’s stab

21. Acute megakaryoblastic leucosis – b. marrow

22. Acute lymphoid leucosis Leycosis of general type Leycosis of general type Т-lymphoblastic Т-lymphoblastic В-lymphoblastic В-lymphoblastic

23. Acute lymphoblastic leucosis – blood. Lymphocytec and lymphoblastes

24. Acute lymphoblastic leucosis - blood

25. Acute В-lymphoblastosis – b. marrow Big vacuolized lymphoblastes

26. Acute lymphoblastic leucosis – b. marrow

27. Acute lymphoblastic leucosis – b. marrow. Initial stage

28. Acute lymphoblastosis – b. marrow Тоtal lymphoblastic metaplasia

29. Chronical myeloid leucosis Myelocytic Myelocytic Monocytic Monocytic Eosinophilic Eosinophilic Erythroblastic Erythroblastic Megakaryocytic Megakaryocytic

30. Chronical myelocytic leucosis – blood. Chronical phase

31. Chronical myeloleucosis – blood Stage of crisis of blastic cells

32. Chronical myelocytic leucosis– blood. Stages of maturate of neutrophils

33. Chronical myeloleucosis – blood. Rejuvenation of cellular staff

34. Chronical myeloleucosis – b. marrow. Unfolded stage

35. Chronical myeloleucosis – b. marrow Stage of crisis of blastic cells

36. Chronical myelocytic leucosis with eosinophilic – b. marrow

37. Chronical myelocytic leucosis, eosinophilic variant – b. marrow

38. Chronical myeloleucosis, basophilic variant Unfolded stage

39. Chronical myeloleucosis, basophilic variant – b. marrow. Stage of crisis of blastic cells

40. Chronical monocytic leucosis - blood

41. Chronical lymphoid leucosis В-lymphocytic В-lymphocytic Т-lymphocytic (1,5 %) Т-lymphocytic (1,5 %) Haircell Haircell

42. Chronical В-cells lymphocytic leucosis - blood

43. Chronical lympholeucosis – blood Nuclear Guprecht ’s shadow

44. Chronical lympholeucosis – b. marrow. Тоtal lymphoid metaplasia

46. Chronical haircell leucosis - blood

48. Haircell leucosis – blood. Acidic phosphatase reaction

49. Mechanisms of activation of cellular oncogenes Point mutation Point mutation Chromosomal aberration Chromosomal aberration Virus transduction Virus transduction Insertious mutagenesis Insertious mutagenesis Genes amplification Genes amplification

50. Clinical manifestation of leucosis Metaplastic аnemia Metaplastic аnemia Thrombocytopenia Thrombocytopenia Hemorrhagic syndrome Hemorrhagic syndrome Secondary immunodeficiency Secondary immunodeficiency Decrease of resistance Decrease of resistance