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Presented By Michael Overman at 2016 ASCO Annual Meeting

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1 Presented By Michael Overman at 2016 ASCO Annual Meeting
Nivolumab ± Ipilimumab in Treatment of Patients With Metastatic Colorectal Cancer With and Without High Microsatellite Instability: <br />CheckMate 142 Interim Results Presented By Michael Overman at 2016 ASCO Annual Meeting

2 Presented By Michael Overman at 2016 ASCO Annual Meeting
Disclosure Presented By Michael Overman at 2016 ASCO Annual Meeting

3 Introduction<br />Nivolumab ± Ipilimumab in Metastatic CRC
Presented By Michael Overman at 2016 ASCO Annual Meeting

4 Presented By Michael Overman at 2016 ASCO Annual Meeting
Hypermutation and Immuno-Oncology:<br />Rationale for Evaluating Nivolumab ± Ipilimumab in CRC Presented By Michael Overman at 2016 ASCO Annual Meeting

5 Ipilimumab and Nivolumab <br />Mechanisms of Action
Presented By Michael Overman at 2016 ASCO Annual Meeting

6 Presented By Michael Overman at 2016 ASCO Annual Meeting
Eligibility Criteria<br />Nivolumab ± Ipilimumab in Metastatic CRC Presented By Michael Overman at 2016 ASCO Annual Meeting

7 Phase 2 CheckMate 142 Study Design: Microsatellite Stable (MSS) Cohort
Presented By Michael Overman at 2016 ASCO Annual Meeting

8 Phase 2 CheckMate 142 Study Design: <br />MSI-H Cohort
Presented By Michael Overman at 2016 ASCO Annual Meeting

9 Study Endpoints<br />Nivolumab ± Ipilimumab in Metastatic CRC
Presented By Michael Overman at 2016 ASCO Annual Meeting

10 Demographics<br />Nivolumab ± Ipilimumab in Metastatic CRC
Presented By Michael Overman at 2016 ASCO Annual Meeting

11 Presented By Michael Overman at 2016 ASCO Annual Meeting
Disease Characteristics and Prior Therapy<br />Nivolumab ± Ipilimumab in Metastatic CRC Presented By Michael Overman at 2016 ASCO Annual Meeting

12 Presented By Michael Overman at 2016 ASCO Annual Meeting
MSI-H Patient Disposition<br />Nivolumab ± Ipilimumab in Metastatic CRC Presented By Michael Overman at 2016 ASCO Annual Meeting

13 Presented By Michael Overman at 2016 ASCO Annual Meeting
Investigator-Assessed Best Overall Response in <br />Patients With MSI-H Receiving Nivolumab Monotherapy Presented By Michael Overman at 2016 ASCO Annual Meeting

14 Presented By Michael Overman at 2016 ASCO Annual Meeting
Investigator-Assessed Best Overall Response in <br />Patients With MSI-H Receiving Nivolumab + Ipilimumab Presented By Michael Overman at 2016 ASCO Annual Meeting

15 Presented By Michael Overman at 2016 ASCO Annual Meeting
Best Reduction in Target Lesion Size <br />in Patients With MSI-H Presented By Michael Overman at 2016 ASCO Annual Meeting

16 Presented By Michael Overman at 2016 ASCO Annual Meeting
Investigator-Assessed PFS in Patients With MSI-H<br />Nivolumab ± Ipilimumab in Metastatic CRC Presented By Michael Overman at 2016 ASCO Annual Meeting

17 Presented By Michael Overman at 2016 ASCO Annual Meeting
OS in Patients With MSI-H<br />Nivolumab ± Ipilimumab in Metastatic CRC Presented By Michael Overman at 2016 ASCO Annual Meeting

18 Presented By Michael Overman at 2016 ASCO Annual Meeting
<br />Summary of Efficacy in Patients With MSS<br />Nivolumab ± Ipilimumab in Metastatic CRC Presented By Michael Overman at 2016 ASCO Annual Meeting

19 Presented By Michael Overman at 2016 ASCO Annual Meeting
Treatment-Related Adverse Events <br />in ≥ 15% of Patients With MSI-H Presented By Michael Overman at 2016 ASCO Annual Meeting

20 Presented By Michael Overman at 2016 ASCO Annual Meeting
Treatment-Related Adverse Events <br />in ≥ 15% of Patients With MSS Presented By Michael Overman at 2016 ASCO Annual Meeting

21 Conclusions<br />Nivolumab ± Ipilimumab in Metastatic CRC
Presented By Michael Overman at 2016 ASCO Annual Meeting

22 Presented By Michael Overman at 2016 ASCO Annual Meeting
Acknowledgments Presented By Michael Overman at 2016 ASCO Annual Meeting

23 CheckMate 142 Investigators
Presented By Michael Overman at 2016 ASCO Annual Meeting


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