1. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 Image Acquisition and Processing Presentation of the overview of the methods used for image acquisition and processing for the study. 2D+t = unsteady 2- dimensional; 1D+t = unsteady 1-dimensional; DIVPD = diastolic intraventricular pressure difference. Figure Legend:

2. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 Results of Intraventricular Flow Decomposition by the Vortex Panel Method The total 2-dimensional velocity field (left) is decomposed in the vortex field (velocity induced by the vortex ring, center) and the irrotational field (velocity directly induced by irrotational inertia, the ventricle and the atrium, right). See the Online Appendix for details. Figure Legend:

3. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 Impact of Vortex Flow on Transmitral Flow Velocity Colored area represents the mean (and standard error bars) of flow velocity measured at the center of the tips of the mitral valve at the time of total peak E-wave velocity, A-wave onset, and peak A-wave velocity. HCM = hypertrophic cardiomyopathy; NIDCM = nonischemic dilated cardiomyopathy. Figure Legend:

4. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 Impact of Vortex Flow on LV Filling Values of vortex filling fraction (proportion of flow entered by the diastolic vortex ring, mean and standard errors) are shown along the filling period for the 3 patient groups. Abbreviations as in Figure 2. Figure Legend:

5. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 M-Mode Analysis of Flow Velocity and Pressure Gradients Through Time One-dimensional representations through time (curvilinear M-mode) of flow velocity (top panels) and diastolic intraventricular pressure gradients (DIVPGs) (bottom panels), for representative examples of subjects from the control (left), NIDCM (center), and HCM (right) groups. The dotted line accounts for the time-varying position of the mitral valve tips during filling. Each panel shows the velocities and pressure gradients projected along the streamline core of the inflow jet. This streamline is visually identified from the 2-dimensional velocity map (see the text and Online Appendix for details). Pressure gradients are depicted as the pressure difference between each pixel location and the LV apex. Notice the absence of late flow propagation due to the lack of vorticity in the HCM patient. Abbreviations as in Figure 2. Figure Legend:

6. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 Intraventricular Pressure Gradients During Diastolic Phases Impact of vortex flow on the intraventricular pressure difference between the LV apex and the base. Mean and standard error bars show the contribution of different flow components for each patient group for 4 phases of cardiac filling. Notice that the vortex and coupling components increase the negative filling pressure gradient toward the apex during E- and A-wave acceleration and reduce the adverse reverse pressure gradient during wave deceleration. Figure Legend:

7. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 Velocity, Filling Volume and DIVPD Waveforms Resulting From Vortex Panel Method Results of flow decomposition by the vortex panel method on flow velocity, filling volume, and intraventricular pressure difference waveforms for a control (left), NIDCM (center), and HCM (right) patient. DIVPD = diastolic intraventricular pressure differences; other abbreviations as in Figure 2. Figure Legend:

8. Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contribution of the Diastolic Vortex Ring to Left Ventricular Filling J Am Coll Cardiol. 2014;64(16):1711-1721. doi:10.1016/j.jacc.2014.06.1205 Vortex Filling Facilitation Versus Sphericity Linear association analysis of vortex mediated filling fraction versus LV sphericity. Horizontal and vertical box plots are overlaid to illustrate how differences in vortex filling fraction among groups is related to differences in sphericity (p < 0.001 for analysis of variance differences in both quantitative variables). Abbreviations as in Figure 2. Figure Legend: