1. CCB Pos/SOs Videoconference – January 17, 2006 Semi-Annual Progress Report Highlights June – November 2005 http://www.loni.ucla.edu/twiki/bin/view/CCB/CCB_NIH_01_17_06_VCon

2. The first maps of how HIV/AIDS damages the brain DBP 2

3. Modeling Large Graphs – e.g., biotech industry http://www.biopostgres.org/PostGraph/biotech/applet.html http://www.biopostgres.org/PostGraph/biotech/applet.html Large Graphs in Computational Biology Large Graphs in Computational Biology TraversalTraversal AnalysisAnalysis VisualizationVisualization Integration – e.g., BrainMapperIntegration – e.g., BrainMapper

4. Correlation between and due to listening to artificial languages Correlation between cortical thickness and brain activation due to listening to artificial languages DBP 1 fMRI task designed to tap word segmentation ability applied to 12 normal kids (9 – 11 y/o). fMRI task designed to tap word segmentation ability applied to 12 normal kids (9 – 11 y/o). Results support the hypothesis that the less mature brain may recruit both hemispheres when faced with learning a novel language. Results support the hypothesis that the less mature brain may recruit both hemispheres when faced with learning a novel language.

5. Brain changes automatically detected in a semantic dementia patient DBP 2 % GM & CSF are computed relative to the initial MRI scan of the patient. % GM & CSF are computed relative to the initial MRI scan of the patient. The profile of disease progression is revealed. The profile of disease progression is revealed.

6. Multimodal registration of mouse brain data: Initial misfit (left) compared to final registration (right) Core1 Aim 1 A novel combined registration and segmentation algorithm is developed and applied to DBP 3 data. A novel combined registration and segmentation algorithm is developed and applied to DBP 3 data.

7. Left – Direct 3D-to-3D mapping; Right - harmonic map result Core1 Aim 1 Advantages over existing Surface mapping methods: Advantages over existing Surface mapping methods: Less distortion during the mapping process.Less distortion during the mapping process. Analysis of the mapping with intrinsic calculus made easy with implicit representations.Analysis of the mapping with intrinsic calculus made easy with implicit representations.

8. Conformal Technology Tool – Conformal parameterization of a hippocampus and a cortical surface Core1 Aim 3 Conformal Mapping identifies intrinsic shape properties! Conformal Mapping identifies intrinsic shape properties!

9. Multimodal 3D Segmentation using Model-based Level Sets (MLS) Core1 Aim 4