1. SKELETAL TISSUE AND PHYSIOLOGY

2. CARTILAGE Connective tissue Fibers embedded in firm gel Avascular Chondrocytes lie in lacunae Nutrients delivered by diffusion

3. 3 TYPES Fibrocartilage – menesci of knee and between vertebrae Elastic – external ear and epiglottis Hyaline – articular, chondral, laryngeal, tracheal and bronchial

4. FUNCTIONS OF SKELETON 1.Support 2.Protection 3.Movement –bones and joints – levers 4.Mineral reservoir – Ca++, Phosphorus 5.Hemopoiesis – blood cell formation

5. TYPES OF BONES 1.Long – humerus, femur, ulna, radius, tibia, fibula 2.Short – carpals and tarsals 3.Flat – skull, ribs, patella, scapula 4.Irregular – vertebrae, facial bones, hyoid

6. MACROSCOPIC STRUCTURE OF LONG BONES 1.Diaphysis – main shaft like portion; hollow, cylindrical, thick compact bone 2.Epiphysis(-es) – end of long bones – bulbous shape provides generous space for muscle attachments – spongy (cancellous) bone filled with yellow marrow except in proximal epiphyses of humerus and femur (red)

7. 3.Articular cartilage – thin layer of hyaline cartilage that covers joint surfaces of epiphyses – shock absorber 4.Periosteum –dense, white fibrous membrane that covers bone everywhere but joint surfaces – Sharpey’s fibers penetrate bone – muscle fibers interlace with these providing a firm anchor – BVs from periosteum nourish bone –

8. - OSTEOBLASTS (bone building cells) compose inner periosteum 5. Medullary cavity – marrow containing cavity in diaphysis 6. Endosteum – membrane lining medullary cavity

10. SHORT, FLAT AND IRREGULAR BONES Cancellous bone covered w/compact bone Red marrow fills spaces in cancellous bone inside a few irregular and flat bones (vertebrae and sternum) Needle aspiration – diagnostic tool

11. BONE TISSUE Connective tissue – cells, fibers (collagen) and calcified matrix More matrix than cells; lots of collagen Strength of cast iron, 1/3 the mass

12. BONE MATRIX 1.Inorganic salts – APATITE (crystals of calcium and phosphate) gives bone its hardness – oriented to resist stress 2.Organic matrix – collagen and ground substance – amorphous mixture of protein and polysaccharides

13. MICROSCOPIC STRUCTURE OF BONE Compact bone composed of Haversian system 1.Lamellae – concentric cylinders of calcified matrix 2.Lacunae – small spaces containing tissue fluid in which osteocytes lie between lamellae 3.Canaliculi – small canals radiating from lacunae, connecting them to each other and the Haversian canal

14. 4.Haversian canal – extends through center of each Haversian system – blood and lymph transport O 2 and nutrients to bone cells - BVs from periosteum penetrate bone via Volkmann’s canals; arteries supply marrow Cancellous bone – NO Haversian systems; weblike arrangement of marrow filled spaces separated by trabeculae (thin processes of bone)

20. BONE MARKINGS A.DEPRESSIONS AND OPENINGS 1.Fossa 2.Sinus 3.Foramen 4.Meatus 5.Sulcus

21. B. PROJECTIONS AND PROCESSES 1. Condyle 2. Head 3. Trochanter 4. Crest 5. Spinous process 6. Tuberosity 7. Tubercle

22. DEVELOPMENT OF BONE - OSTEOGENESIS 1. Intramembranous ossification a.happens in connective tissue membrane b.Includes broad flat bones of the skull c.Membrane like layers of primitive connective tissue appear at the site of future bone d.Layers supplied with blood – connective tissue cells arrange themselves around the blood vessel

23. These cells differentiate into osteoblasts Osteoblasts deposit bony matrix – produce spongy bone Osteoblasts become surrounded by bony matrix – in lacunae, osteocytes Osteoblasts on inside of periosteum give rise to compact bone

27. 2. Endochondral a.Formed from hyaline cartilage model b.Periosteum develops, enlarges, and forms subperiosteal collar c.1 o ossification center develops as cartilage begins to calcify and BVs enter rapidly changing cartilage model at midpoint of diaphysis d.Ossification proceeds from diaphysis to epiphysis e.Bone grows in length

28. f.2 o ossification center appears at epiphyses and growth proceeds from epiphysis to diaphysis g.Until bone length growth is complete, a layer of cartilage (epiphyseal cartilage) remains between diaphysis and epiphysis h.Epiphyseal cartilage thickens during growth periods i.This cartilage ossifies – osteoblasts make organic bone matrix, matrix calcifies – bone grows longer

32. BONE GROWTH AND RESORPTION Bone growth – diameter 1.Osteoclasts 2.Osteoblasts  Ossification and resorption occur concurrently  In adult years, rate =  Childhood and adolescence, ossification > resorption  35- 40 years, resorption > ossification

34. BONE FRACTURES AND REPAIRS Fracture – break in bone’s continuity 1.Simple – skin unbroken 2.Compound – skin broken Alignment = reduction Closed reduction = fracture set without opening skin Open reduction – requires surgical incision Osteomyelitis Kids – greenstick fractures – bone cracked

36. HEALING OF FRACTURES Dead bone – removed by osteoclasts or serves as framework for CALLUS (repair tissue) Callus – periosteal and endosteal cells differentiate into chondroblasts and osteoblasts Callus binds broken ends – callus tissue is eventually replaced by normal bone