1. Uzhhorod National University

2. Uzhhorod National University, Ukraine EU Framework Programme for Research and Innovation "Horizon 2020" CBC program "Hungary- Slovakia-Romania-Ukraine" CBC program "Romania- Ukraine"

3. Uzhhorod National University Aim of the project: Development of a personalized diet approach for the prevention and treatment of diabetes type 2 and other chronic non-communicative diseases relevant to inflammation

4. Uzhhorod National University Objectives: 1)To develop the algorithm of prevention and treatment of non- communicable diseases based on obtained data about effect of edible plant originated foods rich in biologically active substances on mouth / intestinal miсrobiomе, local immune response and lipid metabolism (in diabetes type 2 case); 2) To establishing methodology based on that algorithm for implementation of personilased diet approach to maintain metabolic balance via individual human microbiome; 3) pre-clinical studies, 4) Clinical trial of effect of a personalized diet on intestinal miсrobiomе, local immune response and lipids metabolism of human to diabetes type 2; 5) Creation of the Food composition database in Ukraine; developing the “diet based tool” of prevention and new treatment of non-communicable diseases

5. Uzhhorod National University Main expected results of the project: Decreasing the average of non-communicable diseases in EU and strategic regions) Known mechanisms of regulation by diet based on plants the human miсrobiomе Implementation of algorithm of prevention of non- communicable diseases into medical practice Introduction Food composition database as a potential tool for calculation of human metabolic balance Social impact based on prevalence of active and healthy population

6. Uzhhorod National University Main foreseen activities: Creating personalized diets; Innovative research which is based on the metabolic balance and individual human microbiome; For the first time in Ukraine we will create a database of Ukrainian food products that will be useful and help people monitor the quality of food.

7. Uzhhorod National University Estimated Total Budget 600-800 000,00 EUR Estimated duration 36 months

8. Uzhhorod National University Neem Biotech Ltd Clinical-Microbiomics ApS EPMA Fraunhofer IIS, FIIS Сassovia Life Sciences

9. Uzhhorod National University Scientific Research & Educational Center of MM & IMM, UzNU Nadiya Boyko, director nadiya.boyko@cassovialifesciences.eu Tel.:+380506275445 Viktoriia Bati & Tamara Meleshko, contact persons v.bati@mail.ru meleshkotv@ukr.net