1. w w w. g a l c h i m i a. c o m The leading Medchem service provider in Spain

2. About GalChimia  Based near Santiago de Compostela  Spin-off de la USC  Founded in 2001 by private investors GalChimia is perceived by the clients as dynamic and innovative, specialized in small scale synthesis and medicinal chemistry  >1000 drug discovery projects  > 50 process development performed  > 170 customers worldwide

3. 350 m 2 of laboratories  5 Research labs  1 Development and Scale-up lab (Kilo – lab)  1 Analytical lab A team of 28 people(>40% PhDs), including 19 Chemists Facilities

4.  Multi-step synthesis  Parallel synthesis  Enzymatic reactions  Chiral synthesis & resolution  High Pressure Hydrogenation  Microwave parallel synthesis  Flow chemistry  Reaction Optimization  Heterocyclic chemistry  Functionalized small molecules  Big molecules up to 850Da  Carbohydrates  Cannabinoids  Steroids  Peptidomimetics  Pegylated molecules, …. Contract Research Services We design new routes of synthesis and prepare products (50mg to 10g) USING: OUR EXPERIENCE: We DO NOT work with: F2, Cl2, Ozone and diazomethane, High Potency molecules up to hundreds mg

5. Process Development We develop new process scalable, robust and cost effective  IP evaluation  Route scouting  Process Optimization  Analytical Method Development and Validation  Regulatory Support

6. Custom Synthesis We synthesize different type of compounds for our customers  Scaffold & Building blocks  Lead compound  Analytical standards  Intermediates  Metabolites  Impurities  Advanced Intermediates  Preclinical validation  Clinical Phase I & II  Small quantity of API production NON GMP PRODUCTS GMP BATCHES FOR:

7. Analytical Services  Analytical support to custom synthesis and process R&D projects  Analytical method development & validation according to ICH guidelines  Full analytical characterization of products  Impurities analysis and identification This department gives support to all the others activities of the company  External Services

8. Strengths  EXPERIENCE & EQUIPMENT –14 years working on chemical synthesis  TEAM – highly skilled chemists (>50% with a PhD) CHALLENGING CHEMISTRY COMMUNICATION COMMITMENT  RELIABILITY– driver for business growth  TRANSPARENCY– update on good and bad news  DEDICATION– personal attention to our clients  GLOBAL – from all the team

9. w w w. g a l c h i m i a. c o m Cebreiro s/n 15823 O Pino A Coruña - Spain Tel.: +34 981 814 506 Fax: +34 981 814 507