1. Date of download: 6/24/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association Between Time to Initiation of Adjuvant Chemotherapy and Survival in Colorectal Cancer: A Systematic Review and Meta-analysis JAMA. 2011;305(22):2335-2342. doi:10.1001/jama.2011.749 Validity required that either the comparison groups were balanced for relevant prognostic factors or the reported results were adjusted for these prognostic factors. (Refer to the “Methods” section.) Figure Legend:

2. Date of download: 6/24/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association Between Time to Initiation of Adjuvant Chemotherapy and Survival in Colorectal Cancer: A Systematic Review and Meta-analysis JAMA. 2011;305(22):2335-2342. doi:10.1001/jama.2011.749 A, The relationship between waiting time (WT) categories and overall survival in the 10 studies. Data markers correspond to the midpoint assigned to each WT category. The hazard ratio (HR) represents a comparison with the lowest WT category in each study (reference). Numbers indicate references for the original studies. B, Conversion of HR estimates from the original studies to an HR per unit time of delay. The slope of each line represents the change in the HR per unit of WT. The line for each individual study is located over the range of WTs considered in the study. The blue line and shading indicate the weighted average of the HRs from the individual studies (eg, combined meta-analysis result) and the 95% confidence interval, respectively. Figure Legend:

3. Date of download: 6/24/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association Between Time to Initiation of Adjuvant Chemotherapy and Survival in Colorectal Cancer: A Systematic Review and Meta-analysis JAMA. 2011;305(22):2335-2342. doi:10.1001/jama.2011.749 The size of each data marker represents the weighting factor (1/SE 2 ) assigned to the study. For the combined result, the length of the diamond represents the 95% confidence interval (CI) of the summary. Figure Legend:

4. Date of download: 6/24/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association Between Time to Initiation of Adjuvant Chemotherapy and Survival in Colorectal Cancer: A Systematic Review and Meta-analysis JAMA. 2011;305(22):2335-2342. doi:10.1001/jama.2011.749 Hazard ratio (HR) estimates are the effect per 4 weeks of waiting time. The dotted line indicates the combined HR for all studies of overall survival. Filled circles represent the 10 studies and open circles the studies generated artificially to account for potential publication bias. Figure Legend: