4. 4 Avian influenza (AI) - identified in the early 1900s High pathogenic avian influenza (HPAI) – causes contagious illness, death in birds; Low pathogenic (LPAI) causes mild to no illness Vast majority of AI viruses found in birds do not represent a public health concern

5. 5 HA PB1 PB2 PA NP NA MA NS M2 HemagglutininNeuraminidase M1 Matrix

6. Genetic Reservoirs Intermixing H1, H3 H1, H2, H3 H3, H7 Commercial, LBMs Others H1-12 H14-15 H1-2, 4-7, H9-13, 15-16 H10 H1, H3, H4, H7, H13 Other Aquatic Birds? H5N1