1. A MR Compatible Pressure Transducer with Data Acquisition Software Program Mark Crowe Viral Patel Advisor: Dr. David Pickens

2. Project Purpose The goal of this project is to design and build a pressure transducer to measure vasodilation patterns in males with hypersexuality disorder that can function in a MR environment and also create a software program for data acquisition and storage. The goal of this project is to design and build a pressure transducer to measure vasodilation patterns in males with hypersexuality disorder that can function in a MR environment and also create a software program for data acquisition and storage.

3. Hypersexuality: seen as an out of control pattern of sexual thinking and acting, driven by anxiety reduction rather than desire, as a disorder similar to chemical addiction and closely related to obsessive-compulsiveness, and as a attributable to early childhood abuse and/or neglect.

4. Project Background Joint study between Department of Psychiatry and Department of Radiology. Joint study between Department of Psychiatry and Department of Radiology. fMRI used to determine whether similar brain regions are activated by visual, sexual, and drug- related stimuli. fMRI used to determine whether similar brain regions are activated by visual, sexual, and drug- related stimuli. This study can lead to scientific information concerning the cause and effect of pathological hypersexuality. This study can lead to scientific information concerning the cause and effect of pathological hypersexuality.

5. fMRI fMRI is a technique for determining the region of the brain activated due to physical sensation or activity. fMRI is a technique for determining the region of the brain activated due to physical sensation or activity. Based on increased blood flow Based on increased blood flow The active brain regions of these patients will be compared sexual arousal activation maps in normal males. The active brain regions of these patients will be compared sexual arousal activation maps in normal males.

6. Market Potential This is a built-to-suit device and will only be used for research purposes. This is a built-to-suit device and will only be used for research purposes. No opportunity for individual consumer sales. No opportunity for individual consumer sales. An effort could be made to contact the largest research sites for fMRI around the country. An effort could be made to contact the largest research sites for fMRI around the country. Possible use for testing impotence Possible use for testing impotence Requires input from urologists Requires input from urologists

7. Budget Vanderbilt’s Department of Psychiatry provided: Vanderbilt’s Department of Psychiatry provided: $200 pressure transducer $200 pressure transducer $50 sphygmomanometer $50 sphygmomanometer Vanderbilt’s Department of Radiology provided: Vanderbilt’s Department of Radiology provided: Computer with DaisyLab installed Computer with DaisyLab installed Oscilloscope Oscilloscope Plastic tubing Plastic tubing Any unforeseen costs will be covered by the Psychiatry Dept. Any unforeseen costs will be covered by the Psychiatry Dept. Once project is shown to function properly, a new computer system will be bought solely for the use of this study. Once project is shown to function properly, a new computer system will be bought solely for the use of this study.

8. Experiment Structure Stimulus (Video) Projected onto Screen Subject watches video while in MR magnet Change of pressure in cuff Vasodilation occurs

9. Project Schematic Cuff Pressure Transducer Amplifier Data Acquisition Card Computer

10. Calibration of Tranducer Change of 0.336 V for every 20 mm Hg increase

11. Project Description The pressure transducer is connected to the cuff and to the gauge of a sphygmomanometer. The pressure transducer is connected to the cuff and to the gauge of a sphygmomanometer.

12. Project Description Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Signal sent to computer via data acquisition chip. Signal sent to computer via data acquisition chip.

13. Project Description Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Signal sent to computer via data acquisition chip. Signal sent to computer via data acquisition chip. DaisyLab program created to acquire and store measurements. DaisyLab program created to acquire and store measurements.

14. Project Description Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Signal sent to computer via data acquisition chip. Signal sent to computer via data acquisition chip. DaisyLab program created to acquire and store measurements. DaisyLab program created to acquire and store measurements. Data acquired in real-time. Data acquired in real-time.

15. Project Description Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Pressure measurement from transducer is sent to an amplifier with a coaxial output for the signal. Signal sent to computer via data acquisition chip. Signal sent to computer via data acquisition chip. DaisyLab program created to acquire and store measurements. DaisyLab program created to acquire and store measurements. Data acquired in real-time. Data acquired in real-time. Measurements and time of occurrence stored in a text file for later analysis with Microsoft Excel. Measurements and time of occurrence stored in a text file for later analysis with Microsoft Excel.

17. The MR environment Effect of magnetic field on signal? Effect of magnetic field on signal? Will tubing cause problems with SNR? Will tubing cause problems with SNR?

18. Project Status Pressure transducer has been assembled and calibrated. Pressure transducer has been assembled and calibrated. A software program has been created with DaisyLab for data acquisition. A software program has been created with DaisyLab for data acquisition. Balloon Testing is complete. Balloon Testing is complete.

19. Project Status Device tested on patient outside of MR environment Device tested on patient outside of MR environment Device tested on patient in MR environment Device tested on patient in MR environment

20. Current/Future Work Modifying software program so that ECG data can also be recorded. Modifying software program so that ECG data can also be recorded. Complete by March 15 Complete by March 15 Construction of a container for the device components. Construction of a container for the device components. Complete by March 15 Complete by March 15 Write program for Write program for new computer new computer