6. Genital tract HPV types: LOW RISK: 6, 11, 40, 42, 43, 44; INTERMEDIATE RISK: 31, 33, 35, 51, 52; HIGH RISK: 16, 18, 45, 56

7. HPV-Induced Oncogenesis: Viral Events Integration at the E2 site leads to its deactivation and release of E6 and E7 gene inhibition

8. HPV-Induced Oncogenesis: Cellular Events E6 binds to p53 and induces its degradation. E7 binds the Rb gene product, causing the transcription factor E2F-1 to become unbound and free to induce cell cycle activation/growth.

9. This algorithm generally depicts standard management options for abnormal Pap smears. Options include management of the first ASCUS smear and management of low-grade lesions (LGSIL). Atypical glandular cells of undetermined significance (AGCUS) should lead to consideration of colposcopy, endocervical curettage (ECC), and possibly cone biopsy (Bx).