1. Human Pedigree Analysis

2. Clues for Autosomal Inheritance Clues for Sex-linked Inheritance
Recessive
individual expressing trait has 2 normal parents
two affected parents can not have an unaffected child
Dominant
every affected person has at least one affected parent
each generation will have affected individuals
Clues for Sex-linked Inheritance
no father-to-son transmission
predominantly males affected
trait my skip generations

3. For each of the pedigrees below, identify the mode of inheritance and provide at least 2 reasons for your choice.
Autosomal recessive
Parents and grandparents have normal phenotype
Both males and females affected

4. Autosomal Recessive
Parents, grand parents, and great-grandparents have normal phenotype
Inbred line promotes expression of recessive trait

5. Sex-linked Recessive
Males only
Trait skips generations

6. Autosomal Dominant Each generation has the disease
Each individual has an affected parent

7. Autosomal Recessive Aa
Aa or AA
This is a pedigree for an inherited lung disease. Provide the genotypes of each of the individuals marked with lower case letters.

8. Autsomal Dominant Aa
Aa or AA
This is a pedigree for an inherited brain disease. Provide the genotypes of each of the individuals marked with lower case letters.

9. Use the pedigree for Trait A to determine the genetic basis of this trait.
Does a dominant or recessive allele produce this trait? Explain

10. Is it autosomal or sex-linked? Explain.
Which progeny assures that the trait is autosomal?

11. What are the genotypes of all of the individuals in the pedigree?