1. AMC @ SCI-BUS Sílvia Delgado Olabarriaga e-BioScience Group Bioinformatics Laboratory Dept of Epidemiology, Biostatistics and Bioinformatics

2. Summary AMC AMC & grid e-Bioinfra Challenges Vision for SCI-BUS 2SCI-BUS pre-kick off, London, 6 June 2011

3. Academic Medical Center (AMC) patient care, fundamental and clinical scientific research, and teaching 26,000 patients/year; 7,000 employees; 1500 in research university hospital, faculty of medicine of UvA, Emma Children’s Hospital, many other Institutes and spin-offs SCI-BUS pre-kick off, London, 6 June 20113 http://www.amc.nl/

4. BioInformatics Laboratory Prof. Dr. Antoine van Kampen System Genomics, Semantic Biosystems, e-Bioscience SCI-BUS pre-kick off, London, 6 June 20114 http://www.bioinformaticslaboratory.nl/

5. AMC & Grid 2005: Virtual Laboratory for e-Science project (VL-e) – Medical imaging – VLEMED VO 2008: e-Bioscience group @ biolab – Research, design and evaluate e-science methodology for biomedical research SCI-BUS pre-kick off, London, 6 June 20115

6. e-Bioscience group SCI-BUS pre-kick off, London, 6 June 20116 http://www.ebioscience.amc.nl/ eBioScience eBioImg eBioInfo Medical Imaging Medical Imaging Bioinformatics AMC IT Infra AMC IT Infra Computer Science SOULEY EVERT Paul Groot man y Michel de Vries many VACANCY

7. Vision: e-infrastructure for Bioscience research 7SCI-BUS pre-kick off, London, 6 June 2011 Researcher X Workstation Researcher X Workstation Researcher Z Workstation Researcher Z Workstation Researcher Y Workstation Researcher Y Workstation Researcher W Workstation Researcher W Workstation AMC network AMC Research Gateway (e-BioInfra Gateway) Cluster B Data Acquisition Equipment B Data Acquisition Equipment B Server B Storage Cluster A Data Acquisition Equipment A Data Acquisition Equipment A Server A Storage Cluster C Storage LS grid Cluster LS grid Cluster Grid Cluster Storage Cluster SS Storage Cluster C

8. Strategy 8 User front end e-bioinfra generic services Grid + local services Grid + local resources e-BioScience services Security Research, Collaboration, Software Development and Integration User Support SCI-BUS pre-kick off, London, 6 June 2011

9. Current e-BioInfra SCI-BUS pre-kick off, London, 6 June 20119 Technical, see PUCOWO 8 June, 9:30 User interfaces, see IWSG, June 9, 16:50

10. Challenges Design – Too many middleware options – From computing-centric to data centric – User interfaces Engineering – Changing interfaces and services – Incompatible/conflicting software stacks Operation and Support – “Not developed here” problem – Complexity (simplexity?) SCI-BUS pre-kick off, London, 6 June 201110

11. Hope: SCI-BUS SCI-BUS pre-kick off, London, 6 June 201111 User front end e-bioinfra generic services Grid + local services Grid + local resources e-BioScience services Security

12. Goals in SCI-BUS Develop a scientific gateway for Neuroscience research – AMC & collaborators – Web-based collaboration platform – Data centric – Secure – Support for multiple DCIs Repeat for Next Generation Sequencing – Same/similar requirements? SCI-BUS pre-kick off, London, 6 June 201112

13. Thanks! www.bioinformaticslaboratory.nl S.D.Olabarriaga@amc.uva.nl 13 The e-Bioscience research group currently operates with funding and support from various projects and organizations: BiGGrid project (Dutch Organisation for Scientific Research, NWO), SHIWA and SCI-BUS project (FP7 e-infrastructures), AMC ICT research innovation programme, COMMIT project (Agentschap NL).

14. e-BioInfra IWSG-Life 201114

15. Web Application: System Components PUCOWO 201115

16. Workflow Service IWSG-Life 201116

17. GridSync IWSG-Life 201117