1. Am J Gastroenterol 2010; 105:1820–1829 F1 박재현

2. Background Background A novel mouse line with defects in both transforming growth factor- β type II receptor and interleukin-10 receptor 2 signaling, as well as the T-bet – / – / RAG2 – / – mouse model, rapidly and reproducibly developed a disease resembling severe fulminant human ulcerative colitis. -> completely inhibited by a combination of broad-spectrum antibiotics In 2002, Fusobacterium varium was reported to be present in the colonic mucosa of a high proportion (84 % ) of UC patients. Butyric acid, a product of F. varium culture supernatants, was also shown to cause UC-like lesions in mice.

3. Methods(1) Methods(1)

4. Methods(2) Methods(2) Primary endpoint : clinical response documented by the Mayo score at 3 months after treatment completion Secondary endpoint : clinical and endoscopic score improvements at 12 months

5. Results

12. Conclusion Conclusion The 2-week triple antibiotic therapy produced improvement, remission, and steroid withdrawal in active UC more effectively than a placebo.