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Date of download: 6/26/2016 From: Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in.

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Presentation on theme: "Date of download: 6/26/2016 From: Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in."— Presentation transcript:

1 Date of download: 6/26/2016 From: Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in the United States Ann Intern Med. 2009;151(8):538-545. doi:10.7326/0003-4819-151-8-200910200-00007 Decision tree and cervical cancer natural history model.Women older than 30 years who participate in the U.S. screening program may get vaccinated or continue with screening only. At the start of the analysis, women may reside in any of the mutually exclusive, collectively exhaustive health states denoted by the boxes. Incidence and progression of HPV infection, CIN 1, and CIN 2,3 depend on age and HPV type. Women with previous HPV infection face reduced risks for subsequent type-specific HPV infection because of natural immunity (dashed arrow). Not all health states and transitions are shown. CIN = cervical intraepithelial neoplasia (grade 1 or grade 2 or 3); HPV = human papillomavirus. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2 Date of download: 6/26/2016 From: Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in the United States Ann Intern Med. 2009;151(8):538-545. doi:10.7326/0003-4819-151-8-200910200-00007 Cost-effectiveness of HPV vaccination of screened women, by screening algorithm.Ratios for each strategy with vaccination are calculated compared with the corresponding screening strategy without vaccination. All ratios are expressed as cost, in 2006 U.S. dollars, per QALY. HPV = human papillomavirus; QALY = quality-adjusted life-year. Top. Ratios for HPV vaccination when screening involves cytology with HPV DNA testing for triage of equivocal results. Bottom. Ratios for HPV vaccination when screening involves a switch to combined cytology and HPV DNA testing after age 30 years. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3 Date of download: 6/26/2016 From: Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in the United States Ann Intern Med. 2009;151(8):538-545. doi:10.7326/0003-4819-151-8-200910200-00007 Model fit to HPV prevalence.HPV = human papillomavirus. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4 Date of download: 6/26/2016 From: Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in the United States Ann Intern Med. 2009;151(8):538-545. doi:10.7326/0003-4819-151-8-200910200-00007 Model fit to HPV type distribution among women with CIN and invasive cancer.CIN = cervical intraepithelial neoplasia (grade 1 or grade 2 or 3); HPV = human papillomavirus; HRo = other (non–HPV-16 or HPV-18) high-risk HPV types. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5 Date of download: 6/26/2016 From: Cost-Effectiveness of Human Papillomavirus Vaccination and Cervical Cancer Screening in Women Older Than 30 Years in the United States Ann Intern Med. 2009;151(8):538-545. doi:10.7326/0003-4819-151-8-200910200-00007 Model fit to cervical cancer incidence. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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